Crenezumab's Second Phase 3 Trial (CREAD 2) Fully Recruited - Updates on AC Immune's Pipeline and Technology Platforms to be presented at the Alzheimer's Association International Conference in Chicago Laus

Second Phase 3 Trial (CREAD 2) Fully Recruited

on AC Immune's Pipeline and Technology Platforms to be presented at the Alzheimer's Association International Conference

Lausanne, Switzerland, July

17, 2018 - AC Immune SA (NASDAQ: ACIU), a Swiss-based, clinical-stage biopharmaceutical company focused on neurodegenerative

diseases, today announced that the second Phase 3 (CREAD 2) clinical trial of crenezumab, AC Immune's anti-Abeta antibody

candidate for treatment of Alzheimer's disease, conducted by its partner Genentech, a member of the Roche Group, has completed

Andrea Pfeifer, CEO of AC Immune, commented: "We are very happy that the CREAD 2 recruitment has been completed ahead

of schedule. This clearly shows the strong commitment of our partner Roche/Genentech to the development of crenezumab as a potential

disease-modifying therapy for Alzheimer's disease - one of society's biggest healthcare challenges."

The following updates on AC Immune's

advancement of its in-house and partnered product candidates and technology platforms including crenezumab, will be presented

at the Alzheimer's Association International Conference (AAIC 2018). The conference is the largest international

meeting dedicated to advancing dementia science and takes place in Chicago, US, from July 22nd to 26th,

Crenezumab is an anti-Abeta antibody

discovered by AC Immune using its SupraAntigen technology platform and out-licensed to Genentech, a member of the Roche

group, in 2006 as a potential therapy for Alzheimer's disease. Crenezumab is a fully humanized IgG4 monoclonal antibody

that binds all forms of misfolded Abeta proteins, but especially to Abeta oligomers, to prevent and break up Abeta aggregation

and promote Abeta disaggregation. The IgG4 subclass has reduced effector function, allowing microglia to clear Abeta from the

brain while minimizing an inflammatory response.

Roche/Genentech is currently evaluating

the clinical efficacy and safety of crenezumab in two Phase 3 clinical trials, CREAD 1 and 2, in 750 participants each trial with

prodromal or mild Alzheimer's disease, which started in the first quarter of 2016 and the first quarter of 2017, respectively.

CREAD 1 was fully recruited in the fourth quarter of 2017 and CREAD 2 completed global recruitment in July 2018. In addition,

crenezumab was chosen by an international panel of experts, including the US National Institutes of Health, for use in a first-ever

prevention trial in Alzheimer's disease in a large extended family in Colombia (API ADAD) in 2012.

is a clinical-stage Swiss-based biopharmaceutical company, listed on Nasdaq, which aims to become a global leader in precision

medicine for neurodegenerative diseases. The Company designs, discovers and develops therapeutic as well as diagnostic products

intended to prevent and modify diseases caused by misfolding proteins. AC Immune's two proprietary technology platforms

create antibodies, small molecules and vaccines designed to address a broad spectrum of neurodegenerative indications, such as

Alzheimer's disease (AD). The Company's pipeline features nine therapeutic and three diagnostic product candidates

- with five product candidates currently in clinical trials. The most advanced of these is crenezumab, a humanized anti-amyloid-

monoclonal IgG4 antibody that targets monomeric and aggregated forms of amyloid- , with highest affinity for neurotoxic oligomers.

Crenezumab is currently in two Phase 3 clinical studies for AD, under a global program conducted by the collaboration partner

Genentech (a member of the Roche Group). Other collaborations include Biogen, Janssen Pharmaceuticals, Nestl Institute

of Health Sciences, Piramal Imaging and Essex Bio-Technology.

This press release contains statements

that constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section

21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical fact and may include

statements that address future operating, financial or business performance or AC Immune's strategies or expectations. In

some cases, you can identify these statements by forward-looking words such as "may," "might," "will,"

"should," "expects," "plans," "anticipates," "believes," "estimates,"

"predicts," "projects," "potential," "outlook" or "continue," and

other comparable terminology. Forward-looking statements are based on management's current expectations and beliefs and

involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially

from those contemplated by these statements. These risks and uncertainties include those described under the captions "Item

3. Key Information-Risk Factors" and "Item 5. Operating and Financial Review and Prospects" in AC Immune's

Annual Report on Form 20-F and other filings with the Securities and Exchange Commission. Forward-looking statements speak only

as of the date they are made, and AC Immune does not undertake any obligation to update them in light of new information, future

developments or otherwise, except as may be required under applicable law. All forward-looking statements are qualified in their

entirety by this cautionary statement.

For further information, please