AC Immune to Report Progress of Early Stage Pipeline at AD PD Tm Congress

Lausanne, Switzerland, March 4, 2019- AC Immune SA (NASDAQ: ACIU), a Swiss-based, clinical-stage biopharmaceutical company with a broad pipeline focused on neurodegenerative diseases, today announced that it will provide oral presentations addressing the progress of four of its early-stage product candidates and diagnostics at the 14thInternational Conference on Alzheimer's and Parkinson's Disease (AD/PD), taking place March 26th-31stin Lisbon.

The four oral presentations by AC Immune and its collaborators at AD/PD will focus on AC Immune's partnered and wholly-owned product candidates and technology platform. These presentations will showcase the acceleration and diversification of its early-stage pipeline; specifically, its alpha-synuclein and Tau PET imaging agents as well as preclinical data on compounds targeting Tau aggregation and TDP-43 proteinopathies.

Prof. Andrea Pfeifer, Ph.D., CEO of AC Immune SA, commented: "We appreciate the opportunity to demonstrate the depth of the AC Immune pipeline to the scientific community at AD/PD. These programs highlight the importance of diagnosing and characterizing neurodegenerative diseases earlier. The findings show that our research capabilities have the potential to identify new ways to fight neurodegenerative diseases.  We believe the field is moving toward combination therapy and advancing potential therapeutics like these increases the opportunities to evaluate novel, multi-targeted product candidates."

Alpha-synuclein PET imaging agent

Identification and characterization of selective and high affinity small molecules for positron emission tomography (PET) imaging of pathological alpha-synucleinDate: March 29, 2019 | 8.45 - 9.00 am WETLocation: Auditorium III+IVPresenter: Oral presentation by F. Capotosti

Tau PET imaging agent

Determination of the optimal scanning time for the assessment of Tau deposition in Alzheimer's disease using PI-2620 PETDate: March 29, 2019 | 8.30 - 8.45 am WETLocation: Auditorium III+IVPresenter: Oral presentation by A. Stephens

Compounds targeting Tau aggregation

Small molecules targeting Tau propagation demonstrate efficacy in an aggressive tauopathy mouse modelDate: March 31, 2019 | 11.00 - 11.15 am WETLocation: Auditorium IIPresenter: Oral presentation by S. Poli

Anti-TDP-43 antibodies

Discovery and development of diagnostics and therapeutics for TDP-43 proteinopathiesDate: March 31, 2019 | 11.45 am - 12.00 pm WETLocation: Auditorium IIPresenter: Oral presentation by T. Afroz

About AC Immune SAAC Immune SA is a Nasdaq-listed clinical-stage biopharmaceutical company, which aims to become a global leader in precision medicine for Neurodegenerative Diseases. The Company designs, discovers and develops therapeutic as well as diagnostic products intended to prevent and modify diseases caused by misfolding proteins. AC Immune's two proprietary technology platforms create antibodies, small molecules and vaccines designed to address a broad spectrum of neurodegenerative indications, such as Alzheimer's disease (AD). The Company's pipeline features nine therapeutic and three diagnostic product candidates, with five currently in clinical trials. It has collaborations with major pharmaceutical companies including Roche/Genentech, Lilly, Biogen, Janssen Pharmaceuticals, Nestlé Institute of Health Sciences, Life Molecular Imaging (formerly Piramal Imaging) and Essex Bio-Technology.

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