Full Press Release Details
AC Immune to Receive Research Grant from Goradia
Family for Development of ACI-7104 in Parkinson's Disease
Lausanne, Switzerland, June 11, 2026 -- AC Immune SA (NASDAQ:
ACIU), a clinical-stage biopharmaceutical company pioneering precision therapeutics for neurodegenerative diseases, today announced it
will receive a research grant of $4 million from The Vijay and Marie Goradia Charitable Foundation. The grant will support extending Part
1 of the ongoing Phase 2 VacSYn trial of ACI-7104, AC Immune's anti-alpha-synuclein (a-syn) active immunotherapy, in early Parkinson's
Houston businessman, philanthropist, and cancer survivor Vijay Goradia
and his wife, Marie, established the Vijay and Marie Goradia Charitable Foundation to support health, education, and human services. The
Foundation has previously awarded substantial grants to the University of Texas MD Anderson Cancer Center to speed translational research
and clinical trials.
The long-term dataset enabled by this grant will be particularly valuable
for individuals with prodromal and early PD, who will likely require prolonged treatment and are expected to benefit from a well-established
long-term safety profile.
Vijay Goradia commented: "It is our hope that this grant
will contribute to expanding our knowledge of PD and to bringing ACI-7104 to patients in the earliest stages of disease, before its symptoms
have irreversibly changed the lives of patients and their families. If realized, its potential to slow the rate of progression would revolutionize
the treatment of PD, preserving function and independence for individuals and bringing hope to millions. We are particularly excited and
hopeful about the future potential for ACI-7104 to prevent PD, sparing other families from this disease altogether."
Dr. Andrea Pfeifer, CEO of AC Immune SA, commented: "We
are honored to receive this grant from The Vijay and Marie Goradia Charitable Foundation. ACI-7104 is showing considerable promise in
clinical testing. I would like to thank Vijay and Marie Goradia both for their generous contribution and for their recognition of the
potential of ACI-7104 as AC Immune continues to advance towards precision prevention of neurodegenerative diseases, including PD."
Martin Z gel, MD, interim CEO designate of AC Immune and Chair
of the Board of Directors, commented: "We thank The Vijay and Marie Goradia Charitable Foundation for this grant in support
of our efforts to develop ACI-7104 in early-stage PD. The grant will significantly impact the extension of Part 1 of the VacSYn trial
and enable us to generate vital long-term data on the use of the product in patients."
Positive interim results from the Phase 2 VacSYn trial of ACI-7104 in
early PD were reported in December 2025. These data suggested that targeting a-syn pathology with an active immunotherapy could potentially
have a disease-modifying effect and thus slow the rate of progression of PD. The interim results also indicated a favorable safety profile,
robust and boostable antibody responses, evidence of target engagement, and encouraging clinical signals. Final results from Part 1 of
the trial (to week-104) are expected in H2 2026.
ACI-7104.056 is an optimized formulation of its clinically validated
anti-a-syn predecessor active immunotherapy which generated a target-specific antibody response against pathological oligomeric a-syn
to inhibit spreading and downstream neurodegeneration in early Parkinson's disease. The accumulation of alpha-synuclein protein
aggregates has been shown to cause inflammatory stress in cells and contribute to the degeneration of neurons in the brain. It has been
known to play a key role in the development of neurodegenerative diseases such as Parkinson's Disease.
AC Immune SA is a clinical-stage biopharmaceutical company and a global
leader in precision prevention for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and NeuroOrphan
indications driven by misfolded proteins. The Company's two clinically validated technology platforms, SupraAntigen
and Morphomer , fuel its pipeline of first- and best-in-class assets, which currently features a range of therapeutic and
diagnostic programs, including candidates in Phase 2 and Phase 3 development. AC Immune has a strong track record of securing strategic
partnerships with leading global pharmaceutical companies, resulting in substantial non-dilutive funding to advance its proprietary programs
and >$4.5 billion in potential milestone payments plus royalties.
SupraAntigen is a registered trademark of AC Immune
SA in the following territories: AU, EU, CH, GB, JP, RU, SG and USA. Morphomer is a registered trademark of AC Immune
SA in CA, CN, CH, EU, GB, JP, KR, NO, RU and SG.
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is expressly not incorporated by reference into, and does not constitute a part of, this press release.
For further information, please contact:
SVP, Investor Relations & Corporate Communications
Gary Waanders, Ph.D., MBA
Phone: +41 21 345 91 91
Email: gary.waanders@acimmune.com
Phone: +41 79 367 6254
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