AC Immune Provides Twelve Updates on Its Pipeline at The International Conference on Alzheimer s And Parkinson s Diseases

• Long term safety of crenezumab in an open-label extension of Phase 2 studies in mild-to moderate ADPoster - March 30

• Long term safety and tolerability of escalating doses of crenezumab in patients with mild-to-moderate Alzheimer's diseaseOral Presentation - March 31 / 10:30-10:45

• Crenezumab's preferential binding of oligomeric amyloid-beta species underlies its unique mechanism of actionPoster - April 1

• A Phase 1 study to evaluate the safety and tolerability of RO7105705 in healthy volunteers and patients with mild-to-moderate ADPoster - March 29

• Preclinical characterization, efficacy, pharmacokinetics and pharmacodynamics and safety of RO7105705 - an anti-Tau antibody currently in clinical development for ADOral presentation - March 29 / 10:00-10:15

• Chronic treatment with the murine surrogate of anti-Tau antibody RO7105705 reduces Tau pathology in a transgenic mouse model of tauopathyPoster - March 29

• First in human characterization of PI-2620, a next generation PET tracer for assessing tau in AD and other tauopathiesPoster - March 29

• Characterization of novel PET tracers for the assessment of Tau pathology in AD and other tauopathiesOral presentation - March 31 / 16:15-16:30

• Novel PET Tracers of alpha-Synuclein for thediagnosis of Parkinson's DiseaseOral presentation - March 31 / 16:30-16:45

• Small molecules targeting Tau propagation demonstrate efficacy in an aggressive tauopathy mouse modelOral presentation - April 1 / 15:30-15:45

• The frequency of tau propagation from neuron to neuron is increased in mice carrying the amyloid pathologyPoster - March 29

• A new tool for the profiling of Tau and Abeta in ADPoster - March 29

Selected presentations and posters will be made available at the conclusion of the AD/PDTM2017 Conference onAC Immune's website under the section Science.

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