AC Immune Makes Two Appointments to Executive Committee to Accelerate Product Development Lausanne, Switzerland

AC Immune Makes Two Appointments

to Executive Committee to Accelerate Product Development

Switzerland, February 7, 2019 - AC Immune SA (NASDAQ: ACIU), a Swiss-based, clinical-stage biopharmaceutical company

with a broad pipeline focused on neurodegenerative diseases, today announced two new appointments to its Executive Committee to

accelerate the advancement of its multiple therapeutic candidates through preclinical and clinical development, thereby expanding

and diversifying its pipeline.

Donati joins the Executive Committee and is promoted to Head of Technical Operations and Program Management from his

previous role as Director, Global Program Management at AC Immune. Sonia Poli is promoted to the Executive Committee as

Head of Translational Science. Sonia joined AC Immune in 2018 from her previous role as Chief Scientific Officer at Addex

Andrea Pfeifer, CEO of AC Immune SA, commented: "It is with great pleasure that we welcome Sonia and Piergiorgio to the

AC Immune leadership team. These new roles allow us to increase the impact of our key staff and optimize our development capabilities

as we continue to translate the most promising new scientific discoveries into effective therapies for the treatment of neurodegenerative

Pfeifer added, "Piergiorgio's focus will be on manufacturing and program coordination in order to accelerate the

transition of our preclinical and clinical assets to late stage development. Sonia will guide the seamless transition from early-stage

discovery to preclinical development programs to further enhance the value of our pipeline."

Donati joined AC Immune in June 2018 as Director, Global Program Management, having previously worked for AC Immune from 2011-2015

as Head of Manufacturing and Project Management. With this promotion, Piergiorgio is now Head of Technical Operations and Program

Management. Between 2015 and 2018, Piergiorgio was Head of CMC program development at Glenmark Pharmaceuticals and Biotech CMC

Lead at Merck Group. Prior to 2011, he held R&D positions at Abiogen, Merck Group and Serono. Mr. Donati holds a degree in

Chemistry from the Technical Institute G.L. Bernini.

joined AC Immune from Addex Therapeutics, where she worked for 13 years, and was promoted to Chief Scientific Officer. Prior to

Addex she spent seven years at Roche, most recently as Senior Scientist in the CNS discovery Drug Metabolism and Pharmacokinetics

group. Sonia holds a PhD in Industrial Chemistry from Universit degli Studi di Milano. Dr. Poli is also a member of the

Board of Directors of Dimerix Bioscience.

Immune SA is a Nasdaq-listed clinical-stage biopharmaceutical company, which aims to become a global leader in precision medicine

for Neurodegenerative Diseases. The Company designs, discovers and develops therapeutic as well as diagnostic products intended

to prevent and modify diseases caused by misfolding proteins. AC Immune's two proprietary technology platforms create antibodies,

small molecules and vaccines designed to address a broad spectrum of neurodegenerative indications, such as Alzheimer's disease

(AD). The Company's pipeline features nine therapeutic and three diagnostic product candidates - with five product candidates

currently in clinical trials. The most advanced of these is crenezumab, a humanized anti-beta-amyloid monoclonal IgG4 antibody

that targets monomeric and aggregated forms of beta-amyloid, with highest affinity for neurotoxic oligomers. Crenezumab is currently

in a pivotal clinical study for AD prevention and is licensed to Roche/Genentech. Other collaborations include Lilly, Biogen,

Janssen Pharmaceuticals, Nestl Institute of Health Sciences, Life Molecular Imaging (formerly Piramal Imaging) and Essex

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