AC Immune Appoints Renowned Neurologist Catherine Mummery as Chair of Clinical Advisory Board

AC Immune Appoints Renowned Neurologist Catherine Mummery as Chair of Clinical Advisory Board

Lausanne, Switzerland, October 28, 2025 --AC Immune SA (NASDAQ: ACIU), a clinical-stage biopharmaceutical company pioneering precision therapeutics for neurodegenerative diseases, today announced the appointment of Prof. Catherine Mummery, a deeply experienced neurologist and expert in dementia clinical trials, as Chairwoman of its Clinical Advisory Board (CAB).

Prof. Mummery leads the cognitive disorders service at the UK’s National Hospital for Neurology and Neurosurgery (NHNN), where she has practiced as a consultant neurologist since 2004. She is head of novel therapeutics at the Dementia Research Centre at University College London (UCL), and deputy director for the Leonard Wolfson Experimental Neurology Centre at NHNN, a unit dedicated to early phase trials in neurodegeneration.

She has been senior investigator on more than 20 early-stage studies of disease-modifying agents in dementias, including the first-ever clinical trial of a gene silencing therapy targeting Tau to treat Alzheimer’s disease, as well as trials of AC Immune’s anti-pTau active immunotherapy candidate ACI-35.030 (JNJ-2056).

Dr. Andrea Pfeifer, CEO of AC Immune SA, commented:“It is a great honor that Prof. Mummery has accepted to lead our Clinical Advisory Board. As an investigator on the recently published Phase 1b/2a trial of ACI-35.030 (JNJ-2056), Catherine has been instrumental in the progress we have achieved with our SupraAntigen®immunotherapies. This appointment will now extend her involvement across our entire pipeline of precision prevention candidates, including our three active immunotherapies in Phase 2 development and our most exciting novel therapeutics targeting intracellular mechanisms of neurodegenerative diseases that are approaching the clinic, including ACI-19764 targeting NLRP3, our Morphomer®Tau program, and our Morphomer®a-syn program.”

Prof. Catherine Mummery, Chair of AC Immune’s Clinical Advisory Board, added:“AC Immune is a leader in the development of precision prevention approaches for neurodegenerative diseases, and I am excited by the opportunity to lead its Clinical Advisory Board. I am looking forward to working with and advising the Company’s talented team as its pipeline of active immunotherapies nears meaningful inflection points in clinical trials, plus a series of first-in-class small molecules that enable intracellular targeting of pathologic proteins moving toward the clinic.”

The CAB provides AC Immune with strategic clinical development and regulatory advice and members are selected based on their expertise and peer recognition in the field of neurodegeneration.

As well as Prof. Mummery, the CAB also includes: Dr. Reisa Sperling, Brigham and Women's Hospital and Massachusetts General Hospital, Boston (US); Dr. Murat Emre, Istanbul Faculty of Medicine, Istanbul University, Istanbul (Turkey); Dr. Lon Schneider, Keck School of Medicine of University of Southern California, Los Angeles, CA (US); Dr. Pierre Tariot, Banner Alzheimer’s Institute, Phoenix, AZ (US); and Dr. Juan Fortea, Hospital of Sant Pau, Barcelona (Spain).

Dr. Kaj Blennow, the previous Chairman, is retiring from the CAB. AC Immune thanks Dr. Blennow for his support and invaluable guidance.

About AC Immune SA

AC Immune SA is a clinical-stage biopharmaceutical company and a global leader in precision prevention for neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and NeuroOrphan indications driven by misfolded proteins. The Company’s two clinically validated technology platforms, SupraAntigen® and Morphomer®, fuel its broad and diversified pipeline of first- and best-in-class assets, which currently features a range of therapeutic and diagnostic programs, including candidates in Phase 2 and Phase 3 development. AC Immune has a strong track record of securing strategic partnerships with leading global pharmaceutical companies, resulting in substantial non-dilutive funding to advance its proprietary programs and >$4.5 billion in potential milestone payments plus royalties.

SupraAntigen® is a registered trademark of AC Immune SA in the following territories: AU, EU, CH, GB, JP, RU, SG and USA. Morphomer® is a registered trademark of AC Immune SA in CN, CH, EU, GB, JP, KR, NO, RU and SG.

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