Full Press Release Details
• New data from the API ADAD Study to be presented in AAICFocused Topic Session
• New Phase 2 results from investigator-sponsored trial of the Tau PET tracer PI-2620 in Alzheimer’s disease
• First-time presentation of innovative biomarker-based translational clinical trial design to evaluate ACI-24.060 in sporadic Alzheimer’s disease and in people with Down syndrome
• Additional data from proof-of-concept clinical study of ACI-12589 PET tracer to detect alpha-synuclein in the brains of living patients
LAUSANNE, Switzerland, July 22, 2022 (GLOBE NEWSWIRE) -- AC Immune SA (NASDAQ: ACIU), a Swiss-based, clinical-stage biopharmaceutical company with a broad pipeline focused on neurodegenerative diseases, today announced 10 upcoming presentations that will be delivered at the Alzheimer’s Association International Conference (AAIC) in San Diego, California (United States) and online, July 31 – August 4, 2022.
Dr. Andrea Pfeifer, CEO of AC Immune SA, commented: “With new data on therapeutic and diagnostic candidates addressing multiple targets, the upcoming AAIC presentations will showcase our aim to shift the therapeutic paradigm towards earlier treatment and prevention in order to address Alzheimer’s and other neurodegenerative disease. We look forward to learning more about the impact of the API ADAD study. And, we are delighted to announce during AAIC the fourth of seven clinical readouts due this year: new results from our PI-2620 Tau PET tracer Phase 2 trial in people with Alzheimer’s disease.”
There will be multiple presentations by AC Immune’s partners with Genentech covering the crenezumab and semorinemab partnerships. New Phase 2 clinical Alzheimer’s data on the Tau-PET tracer PI-2620, partnered with Life Molecular Imaging (LMI), will be announced during the conference and presented at a workshop organized by LMI.
Additional presentations feature: new patient scans from the proof-of-concept clinical study of ACI-12589; AC Immune’s wholly owned alpha-synuclein PET tracer; and, new preclinical data on ACI-24.060, the Company’s wholly owned anti-Abeta vaccine. Preclinical data on ACI-12589 and the design of an innovative, adaptive translational Phase 1b/2a trial of ACI-24 in patients with Alzheimer’s disease and individuals with Down syndrome also will be presented.
AC Immune pipeline at AAIC 2022
| Abstract Title | Presentation typeLocationPresentation Date, Time (PT)Author/Presenter |
| Crenezumab Abeta antibody | |
| API ADAD Colombia Trial initial findings: a randomized, double-blind, placebo-controlled, parallel- group study in cognitively unimpaired PSEN1 E280A mutation carriers evaluating efficacy and safety of crenezumab | Focused topic sessionBallroom 20A - San Diego Convention CenterTues, Aug 02, 8:00 am - 08:45 amRachelle S. Doody, MD, PhD, (Genentech/Roche) |
| Clinical Profiles of Persons Who Progress to Cognitive Impairment in the Alzheimer’s Prevention Initiative (API) ADAD Colombia Trial | Virtual PosterSun, Jul 31 - 9:00 am - 4:15 pmAAIC Virtual platformMargarita Giraldo-Chica (Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia) |
| Semorinemab Tau antibody | |
| Evaluation Of Longitudinal [18F]GTP1 Tau Burden Metrics In The Tauriel Phase II Study | Hybrid oral sessionBallroom 20A - San Diego Convention CenterSun, Jul 31, 11:35 am - 11:45 amSandra Sanabria Bohorquez, PhD (Genentech/Roche) |
| Selecting appropriate meaningful change thresholds for trials of early (prodromal-to-mild) AD: A caregiver-rated, anchor-based analysis based on the Tauriel Study | Virtual oral sessionAAIC Virtual platformMon, Aug 01, 12:05 pm - 12:15 pmEdmond Teng, MD, PhD (Genentech/Roche) |
| PI-2620 Tau-PET Tracer | |
| In Vivo Head-To-Head Comparison Of [18f]GTP1 And [18f]PI2620 In Alzheimer’s Disease | PosterExhibit Hall -- DEF - San Diego Convention CenterSat, Jul 30, 12:25 pm - 1:40 pmSandra Sanabria Bohorquez, PhD (Genentech/Roche) |
| One year longitudinal change of Tau accumulation on [18F]PI-2620 PET in Alzheimer spectrum | Virtual posterAAIC Virtual platformSun, July 31, 7:00 am - 11:55 pmMinyoung Oh, MD, PhD, (Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea) |
| ACI-12589 alpha-syn imaging agent | |
| Discovery of [18F] ACI-12589, a novel and promising PET-tracer for alpha-synuclein | Hybrid oral sessionBallroom 20A - San Diego Convention CenterSun, July 31, 11:15 am - 11:25 amFrancesca Capotosti, Ph.D. (AC Immune) |
| Initial clinical scans using [18F]ACI-12589, a novel α-synuclein PET-tracer | Hybrid oral sessionBallroom 20A - San Diego Convention CenterSun, July 31, 11:25 am - 11:35 amProf. Ruben Smith (Skåne University Hospital, Lund, Sweden) |
| ACI-24 anti-Abeta vaccine | |
| Optimized ACI-24, an amyloid beta (Abeta) vaccine that safely drives immunity to oligomers and pyroglutamate Abeta, key pathological species of Alzheimer’s disease (AD) | Hybrid oral sessionBallroom 20A - San Diego Convention CenterAugust 2, 2022, 11:15 am - 11:25 amE. Fiorini, Ph.D. (AC Immune) |
| Biomarker-based development for optimized ACI-24, a novel candidate vaccine for the treatment and prevention of Alzheimer’s disease | In-person posterBallroom 20A - San Diego Convention Center - P1-040Sun July 31, 12:30 pm - 2:15 pmProf. Johannes Streffer, MD. (AC Immune) |
• Presentation type
• Location
• Presentation Date, Time (PT)
• Author/Presenter
• Focused topic session
• Ballroom 20A - San Diego Convention Center
• Tues, Aug 02, 8:00 am - 08:45 am
• Rachelle S. Doody, MD, PhD, (Genentech/Roche)
• Virtual Poster
• Sun, Jul 31 - 9:00 am - 4:15 pm
• AAIC Virtual platform
• Margarita Giraldo-Chica (Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellin, Colombia)
• Hybrid oral session
• Ballroom 20A - San Diego Convention Center
• Sun, Jul 31, 11:35 am - 11:45 am
• Sandra Sanabria Bohorquez, PhD (Genentech/Roche)
• Virtual oral session
• AAIC Virtual platform
• Mon, Aug 01, 12:05 pm - 12:15 pm
• Edmond Teng, MD, PhD (Genentech/Roche)
• Poster
• Exhibit Hall -- DEF - San Diego Convention Center
• Sat, Jul 30, 12:25 pm - 1:40 pm
• Sandra Sanabria Bohorquez, PhD (Genentech/Roche)
• Virtual poster
• AAIC Virtual platform
• Sun, July 31, 7:00 am - 11:55 pm
• Minyoung Oh, MD, PhD, (Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea)
• Hybrid oral session
• Ballroom 20A - San Diego Convention Center
• Sun, July 31, 11:15 am - 11:25 am
• Francesca Capotosti, Ph.D. (AC Immune)
• Hybrid oral session
• Ballroom 20A - San Diego Convention Center
• Sun, July 31, 11:25 am - 11:35 am
• Prof. Ruben Smith (Skåne University Hospital, Lund, Sweden)
• Hybrid oral session
• Ballroom 20A - San Diego Convention Center
• August 2, 2022, 11:15 am - 11:25 am
• E. Fiorini, Ph.D. (AC Immune)
• In-person poster
• Ballroom 20A - San Diego Convention Center - P1-040
• Sun July 31, 12:30 pm - 2:15 pm
• Prof. Johannes Streffer, MD. (AC Immune)
About AC Immune SAAC Immune SA is a clinical-stage biopharmaceutical company that aims to become a global leader in precision medicine for neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and NeuroOrphan indications driven by misfolded proteins. The Company’s two clinically validated technology platforms, SupraAntigen®and Morphomer®, fuel its broad and diversified pipeline of first- and best-in-class assets, which currently features ten therapeutic and three diagnostic candidates, six of which are currently in clinical trials. AC Immune has a strong track record of securing strategic partnerships with leading global pharmaceutical companies including Genentech, a member of the Roche Group, Eli Lilly and Company, and Janssen Pharmaceuticals, Inc., resulting in substantial non-dilutive funding to advance its proprietary programs and >$3 billion in potential milestone payments.
SupraAntigen®is a registered trademark of AC Immune SA in the following territories: AU, EU, CH, GB, JP and RU. Morphomer®is a registered trademark of AC Immune SA in CN, CH, GB, JP, and NO.
| Media RelationsSaoyuth NidhAC ImmunePhone: +41 21 345 91 34Email:saoyuth.nidh@acimmune.com | Investor RelationsGary Waanders, Ph.D., MBAAC ImmunePhone: +41 21 345 91 91Email:gary.waanders@acimmune.com |
| U.S. MediaShani LewisLaVoieHealthSciencePhone: +1 609 516 5761Email:slewis@lavoiehealthscience.com | U.S. InvestorsCorey Davis, Ph.D.LifeSci AdvisorsPhone: +1 212 915 2577Email:cdavis@lifesciadvisors.com |
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