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Achieve Life Sciences Joins Russell 2000® Index

Key Takeaway: Achieve Life Sciences has been added to the Russell 2000 Index as of June 26, 2026. This inclusion is significant as the Russell 2000 Index is a key benchmark for small-cap U.S. equities, potentially increasing the company's visibility among institutional investors. Achieve focuses on developing cytisinicline for nicotine dependence, supported by successful clinical studies.
Price reaction · baseline $6.02 (2026-06-26 close) · hit pre-market · clean, no other ACHV news in the window
day 0 close · peak
+3.5%

Market Sentiment Analysis

POSITIVE FACTORS

  • Achieve Life Sciences joins the prestigious Russell 2000 Index.
  • Inclusion may enhance visibility and attract institutional investors.
  • Cytisinicline shows promise as a treatment for nicotine dependence.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+146%
120-day peak, hindsight
Typical move
3.2%
average across 2 past catalysts
Cash runway
~52 mo
Minimal dilution risk
Lead asset
Custirsen, paclitaxel and carboplatin
Phase 1 · Cancer

Full Press Release Details

SEATTLE and VANCOUVER, British Columbia, June 29, 2026 (GLOBE NEWSWIRE) -- Achieve Life Sciences, Inc. (Achieve or the Company) (Nasdaq: ACHV), a late-stage specialty pharmaceutical company focused on the global development and commercialization of cytisinicline as a treatment for nicotine dependence, today announced that it has been added to the Russell 2000® Index, effective June 26, 2026, as part of the Russell U.S. Indexes reconstitution. The Company is also a member of the Russell 3000® Index.
Approximately $12.2 trillion in assets, as of June 30, 2025, are benchmarked against the Russell U.S. Indexes, making them one of the most widely used benchmarks for institutional investors, index-tracking funds, and active investment strategies. The Russell 2000® Index measures the performance of approximately 2,000 small-cap U.S. equities, and the Russell 3000® Index measures the performance of approximately 3,000 of the largest U.S. stocks, representing approximately 98% of investable U.S. equities by market capitalization. FTSE Russell determines membership for its Russell indexes primarily by objective, market-capitalization rankings and style attributes.
About CytisiniclineThere are approximately 25 million adults in the United States who smoke combustible cigarettes.¹ Cytisinicline is a plant-based alkaloid with a high binding affinity to the nicotinic acetylcholine receptor. It is believed to aid in treating nicotine addiction for smoking and e-cigarette cessation by interacting with nicotine receptors in the brain, reducing the severity of nicotine craving symptoms, and reducing the reward and satisfaction associated with nicotine products.
About Achieve Life Sciences, Inc.Achieve Life Sciences, Inc. is a late-stage specialty pharmaceutical company focused on the global development and commercialization of cytisinicline as a treatment of nicotine dependence. Achieve’s New Drug Application (NDA) for cytisinicline for smoking cessation in adults is supported by two successfully completed Phase 3 studies and an open-label long-term safety study. Achieve has also completed a Phase 2 study of cytisinicline in nicotine e-cigarette cessation, conducted an end-of-Phase 2 meeting with the FDA, and has received Breakthrough Therapy designation for the vaping cessation indication.
Forward Looking StatementsThis press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements Achieve makes regarding the timing, nature and outcome of cytisinicline clinical development and regulatory review and approval, data results, the timing, nature and success of Achieve’s commercialization activities, the potential market size for cytisinicline, the potential benefits, efficacy, safety and tolerability of cytisinicline, the development and effectiveness of new treatments, the performance of Achieve’s third-party manufacturing partners, the successful launch and commercialization of cytisinicline, and statements concerning Achieve Life Sciences’ future plans and prospects. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. Achieve may not actually achieve its plans or product development goals in a timely manner, if at all, or otherwise carry out its intentions or meet its expectations or projections disclosed in these forward-looking statements. These statements are based on management’s current expectations and beliefs and are subject to a number of risks, uncertainties and assumptions that could cause actual results to differ materially from those described in the forward-looking statements, including those described in Achieve’s Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q. Achieve undertakes no obligation to update the forward-looking statements contained herein or to reflect events or circumstances occurring after the date hereof, other than as may be required by applicable law.

Achieve ContactNicole JonesVP, Strategic Communications and Stakeholder Relationsir@achievelifesciences.com425-686-1510

References¹Agaku I. Tobacco Product Use among U.S. Adults, 2023–2024, NEJM, doi: 10.1056/EVIDpha2500339.

Frequently Asked Questions

What is the significance of joining the Russell 2000?

Joining the Russell 2000 Index enhances Achieve's visibility and may attract institutional investors.

What is cytisinicline used for?

Cytisinicline is developed as a treatment for nicotine dependence, aiding in smoking cessation.

When did Achieve join the Russell 2000 Index?

Achieve Life Sciences was added to the Russell 2000 Index on June 26, 2026.

What studies support cytisinicline's development?

Cytisinicline's development is supported by two completed Phase 3 studies and a long-term safety study.

Last updated: Jun 29, 2026