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Achieve Life Sciences Reports Financial Results for Fourth Quarter and Year-End 2024 and Provides Update on the Cytisinicline Development Program

Key Takeaway: Achieve Life Sciences has reported its financial results for Q4 and year-end 2024, highlighting significant progress in its Cytisinicline development program. The company confirmed the completion of enrollment in the ORCA-OL trial and positive DSMC reviews. Additionally, it announced plans for an NDA submission by the end of Q2 2025 and new leadership appointments.
Price reaction · baseline $2.73 (2025-03-19T15:44:00.000Z) · hit during market hours · clean, no other ACHV news in the window
day 0 close · peak
-2.2%

Market Sentiment Analysis

POSITIVE FACTORS

  • Successful completion of enrollment in ORCA-OL trial.
  • Positive outcomes from DSMC reviews with no safety concerns.
  • NDA submission planned for Q2 2025.
  • New appointments to the Board enhance leadership.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+146%
120-day peak, hindsight
Typical move
3.2%
average across 2 past catalysts
Cash runway
~52 mo
Minimal dilution risk
Lead asset
Custirsen, paclitaxel and carboplatin
Phase 1 · Cancer

Full Press Release Details

Reiterates Planned Cytisinicline NDA Submission Expected at the End of Q2 2025

Company to Host Conference Call at 8:30 AM EDT Today, Tuesday, March 11, 2025

• Reached key milestones in the ORCA-OL long-term exposure trial, including completion of enrollment and meeting the requirement of 300 participants receiving six months of cumulative cytisinicline treatment, as required for the submission of the NDA
• Announced positive outcomes from two data safety monitoring committee (DSMC) reviews with no safety concerns in the ORCA-OL clinical trial
• Appointed Dr. Kristen Slaoui and Nancy Phelan to the Board of Directors, bringing extensive leadership experience in corporate strategy and commercialization
• Appointed Mark Oki as Chief Financial Officer to oversee the company’s financial strategy and operational initiatives
• Announced the successful outcome of the End-of-Phase 2 meeting with the U.S. Food and Drug Administration (FDA) for defining cytisinicline development as a treatment for vaping cessation

Frequently Asked Questions

What are the key milestones achieved in the ORCA-OL trial?

The ORCA-OL trial has completed enrollment and met the requirement of 300 participants receiving six months of cytisinicline treatment.

When is the NDA submission for Cytisinicline planned?

The NDA submission for Cytisinicline is expected at the end of Q2 2025.

What were the outcomes of the DSMC reviews?

The DSMC reviews reported positive outcomes with no safety concerns in the ORCA-OL clinical trial.

Who were the new appointments to the Board of Directors?

Dr. Kristen Slaoui and Nancy Phelan were appointed to the Board, bringing extensive leadership experience.

Who is the new Chief Financial Officer?

Mark Oki has been appointed as the Chief Financial Officer to oversee the company's financial strategy.

Last updated: Mar 19, 2025