Full Press Release Details
Acumen presents poster describing method to standardize amyloid beta oligomer assays supporting
therapeutic development for early Alzheimer s disease
Model designed to fill need for soluble amyloid beta
oligomer reference standards in bioanalytical assays
Charlottesville, Va. and Carmel, Ind. (August 1, 2022) Scientists at Acumen
Pharmaceuticals, Inc. (NASDAQ: ABOS) have developed a synthetic model to potentially standardize the study of soluble amyloid beta oligomers, (A Os), toxic proteins that accumulate early in Alzheimer s disease (AD). This methodology
will be presented in a poster at the Alzheimer s Association International Conference (AAIC), held in-person in San Diego and virtually between July 31 and Aug. 4, 2022.
Studies suggest toxic soluble A Os contribute to AD-associated memory and cognitive problems. However, soluble
A Os have been challenging to model in the laboratory as their structures in the brain are difficult to characterize due to their low concentration and instability, and because they appear in various forms. To adequately study soluble
A Os, standardized analytical tools are required.
Utilizing A -derived diffusible ligands (ADDLs) as a synthetic A O model may aid in
standardization of A O assays. For example, using ADDL assays to better understand the specificity and selectivity of A -targeting antibodies may support therapeutic development. Other expected uses for ADDLs are as a quantitative
standard in assays aimed at measuring soluble A Os or A O auto-antibodies in patient biofluids.
These research efforts towards
developing a reliable model of A Os will contribute to the greater body of knowledge around oligomers and Alzheimer s disease, said Eric Siemers, M.D., Chief Medical Officer at Acumen Pharmaceuticals. A Os have been a
lesser studied target in Alzheimer s disease. We expect our ongoing Phase 1 clinical trial of ACU193 to provide proof of mechanism data that we believe will shed additional light on the role of oligomers in Alzheimer s disease. The
poster, Preparation and qualification of soluble amyloid beta oligomers for use in bioanalytic assays supporting Alzheimer s disease therapeutics (P4-178), will be presented on Wednesday, Aug.
3, 2022 and is viewable on the AAIC conference website to registrants through Sept. 2, 2022.
About Acumen Pharmaceuticals, Inc.
Acumen, headquartered in Charlottesville, VA, with clinical operations based in Carmel, IN, is a clinical stage biopharmaceutical company developing a novel
disease-modifying approach to treat Alzheimer s disease. Acumen s scientific founders pioneered research on A Os, which a growing body of evidence indicates are primary triggers of Alzheimer s disease pathology. Acumen is
currently focused on advancing its investigational product candidate, ACU193, a humanized monoclonal antibody that selectively targets toxic soluble A Os in INTERCEPT-AD, a Phase 1 clinical trial
involving early Alzheimer s disease patients. For more information, visit www.acumenpharm.com.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform
Act of 1995. Any statement describing Acumen s goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Words such as believes, expects, anticipates, could, would, seeks, aims, plans,
potential, will and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain
these identifying words. Forward-looking statements include statements concerning Acumen s business and the therapeutic potential of Acumen s product candidate, ACU193, including its potential for
improved safety and efficacy as compared to other monoclonal antibodies in development, as well as the expectations concerning the INTERCEPT-AD trial and expectations with respect to the role of toxic soluble
A Os in the potential treatment of Alzheimer s disease. These statements are based upon the current beliefs and expectations of Acumen management, and are subject to certain factors, risks and uncertainties, particularly those inherent in
the process of discovering, developing and commercializing safe and effective human therapeutics. Such risks may be amplified by the impacts of the COVID-19 pandemic. These and other risks concerning
Acumen s programs are described in additional detail in Acumen s filings with the Securities and Exchange Commission ( SEC ), including in Acumen s Annual Report on Form 10-K for the
year ended December 31, 2021, filed with the SEC on March 28, 2021, which is available on the SEC s website at www.sec.gov, and its other documents subsequently filed with or furnished to the SEC. Copies of these and other
documents are available from Acumen. Additional information will be made available in other filings that Acumen makes from time to time with the SEC. These forward-looking statements speak only as of the date
hereof, and Acumen expressly disclaims any obligation to update or revise any forward-looking statement, except as otherwise required by law, whether, as a result of new information, future events or