Full Press Release Details
NORTH CHICAGO, Ill. , Nov. 13, 2014 /PRNewswire/ -- AbbVie (NYSE: ABBV ) announced that data from 37 abstracts related to HUMIRA ® (adalimumab), rheumatologic diseases and investigational medicines will be presented at the upcoming 2014 American College of Rheumatology (ACR) Annual Meeting, November 14 – 19, in Boston . As a long-standing expert in the field of rheumatology with its experience with HUMIRA, AbbVie continues to build on its leadership with data focused on investigational medicines to create innovative solutions for rheumatologic diseases.
"AbbVie's 37 abstracts at ACR demonstrate the breadth of the company's ongoing commitment to research innovative solutions that address chronic, progressive diseases like rheumatoid arthritis, osteoarthritis and lupus," said Scott Brun , vice president, pharmaceutical development, AbbVie. "We continue to build on our more than 17 years of experience in rheumatologic disease management with HUMIRA by applying our scientific expertise to address unmet needs and impact the standard of care for people living with a range of immune-mediated diseases."
Six abstracts on AbbVie's investigational medicines, including two oral presentations, highlight data supporting innovative approaches to treat lupus, osteoarthritis and rheumatoid arthritis. Data will spotlight ABT-122, a novel dual variable domain immunoglobulin (DVD-Ig™) being studied to treat certain immunologic disorders by blocking both TNF and IL-17, and ABT-199, a selective BCL-2 inhibitor directed toward B-cell pathways contributing to autoimmunity in lupus.
HUMIRA data to be presented focus on long-term safety and effectiveness in juvenile idiopathic arthritis, treatment of early rheumatoid arthritis and a cost per responder analysis of treatments for psoriatic arthritis.
In the United States , HUMIRA was approved in 2002 for the treatment of moderate to severe rheumatoid arthritis and is now approved for eight indications, including psoriatic arthritis, ankylosing spondylitis and moderate to severe polyarticular juvenile idiopathic arthritis. Outside of the United States , HUMIRA is approved for 10 indications.
Selected Abstracts of Interest Abstracts are available to registered journalists here .
Investigational Medicines Abstracts of Interest
HUMIRA (AbbVie-sponsored) Abstracts of Interest
About HUMIRA Uses HUMIRA is a prescription medicine used:
Important Safety Information HUMIRA is a TNF blocker medicine that affects the immune system and can lower the ability to fight infections. Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. People should be tested for TB before HUMIRA use and monitored for signs and symptoms of TB during therapy. People at risk of TB may be treated with medicine for TB. Treatment with HUMIRA should not be started in a person with an active infection, unless approved by a doctor. HUMIRA should be stopped if a person develops a serious infection. People should tell their doctor if they live in or have been to a region where certain fungal infections are common, have had TB, hepatitis B, are prone to infections, or have symptoms such as fever, fatigue, cough, or sores.
For people taking TNF blockers, including HUMIRA, the chance of getting lymphoma or other cancers may increase. Some people have developed a rare type of cancer called hepatosplenic T-cell lymphoma. This type of cancer often results in death. If using TNF blockers including HUMIRA, the chance of getting two types of skin cancer (basal cell and squamous cell) may increase. These types are generally not life- threatening if treated.
Other possible serious side effects with HUMIRA include hepatitis B infection in carriers of the virus; allergic reactions; nervous system problems; blood problems; certain immune reactions, including a lupus-like syndrome; liver problems; and new or worsening heart failure or psoriasis. The use of HUMIRA with anakinra or abatacept is not recommended. People using HUMIRA should not receive live vaccines.
Common side effects of HUMIRA include injection site reactions (redness, rash, swelling, itching, or bruising), upper respiratory infections (including sinus infections), headaches, rash, and nausea.
HUMIRA is given by injection under the skin.
The benefits and risks of HUMIRA should be carefully considered before starting therapy.
Please click here for the Full Prescribing Information and Medication Guide.
Globally, prescribing information varies; refer to the individual country product label for complete information.
About AbbVie AbbVie is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company's mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world's most complex and serious diseases. AbbVie employs approximately 25,000 people worldwide and markets medicines in more than 170 countries. For further information on the company and its people, portfolio and commitments, please visit www.abbvie.com . Follow @abbvie on Twitter or view careers on our Facebook or LinkedIn page.
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Additional information about the economic, competitive, governmental, technological and other factors that may affect AbbVie's operations is set forth in Item 1A, "Risk Factors," in AbbVie's 2013 Annual Report on Form 10-K, which has been filed with the Securities and Exchange Commission. AbbVie undertakes no obligation to release publicly any revisions to forward-looking statements as a result of subsequent events or developments, except as required by law.