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Hepatitis B: one US-listed biotech with a clinical-stage programme

Infectious Disease & VaccinesUncontestedData as of 2026-09-04

Competitors1in the clinic
Median market cap$203Muniverse median $1.20B
Allocated capital$13M$203M competing
Phase 3 or filed00 mid, 1 early
Pure plays0this indication only
Capital rank299/299crowding rank 299

Hepatitis B is uncontested. Precision BioSciences (DTIL) is the only US-listed developer in the $100M to $20B band running a clinical programme here, with PBGENE-HBV in phase 1.

There is no public comparable to price it against. DTIL spreads its $203M market cap across 16 indications, so $13M of it is allocated here.

Nothing here has reached Phase 3: 0 programmes in mid stage and 1 in early stage, so the field is still several years from a first approval.

$13M of allocated capital sits in Hepatitis B, ranking it 299th of 299 indications by the money committed to it.

Companies developing drugs for Hepatitis B 1

TickerCompanyLead assetPhaseTrialsMarket capPure playIndicationsNext catalyst
DTILPrecision BioSciencesPBGENE-HBVPhase 11$203MNo16 31 Dec 2026

Sorted by phase, then by market capitalisation. Ticker links open the company profile.

Why Hepatitis B counts as uncontested

Uncontested. One US-listed developer in the size band is running a clinical programme here, so there is no public comparable to price it against.

The map splits indications on two folds: six or more competitors counts as crowded, and a median company above $1.20B counts as richly priced. Hepatitis B has one competitor and a median of $203M.

Infectious Disease & Vaccines

Infectious Disease & Vaccines holds $16.5B of the map's capital, 2.5% of the total, spread across 13 indications and 10 companies. 0 of those indications have more than one company competing.

See every Infectious Disease & Vaccines indication on the map

Related indications in Infectious Disease & Vaccines

Smallpox1 company · $232M · median $232MUncontestedRSV Infection1 company · $408M · median $408MUncontestedHepatitis C1 company · $467M · median $467MUncontestedChronic Hepatitis B1 company · $484M · median $1.9BUncontestedCompensated Chronic Hepatitis B1 company · $484M · median $1.9BUncontestedSepsis1 company · $723M · median $8.7BUncontestedMycobacterium Abscessus Infection1 company · $771M · median $1.5BUncontestedIntra-Abdominal Infections1 company · $771M · median $1.5BUncontested

Hepatitis B pipeline questions

Which biotech companies are developing drugs for Hepatitis B?

Precision BioSciences (DTIL, PBGENE-HBV, Phase 1). Those are the 1 US-listed developer in the $100M to $20B market cap band with a clinical-stage programme in Hepatitis B.

How advanced is the Hepatitis B pipeline?

Of the 1 clinical-stage programme in Hepatitis B, 0 are in Phase 3 or filed, 0 are in mid-stage development and 1 is in early-stage development.

Is anyone else developing a drug for Hepatitis B?

No. DTIL is the only US-listed company in the $100M to $20B market cap band with a clinical-stage programme in Hepatitis B, which is why the indication is classified as uncontested.

When is the next Hepatitis B catalyst?

The next dated catalyst in Hepatitis B is DTIL on 31 Dec 2026. 1 dated event across the field fall in the next 12 months.

How this page is built

  • Universe is US-listed drug developers with a $100M to $20B market capitalisation, identified by SEC SIC code 2833, 2834 or 2836 or by a pharmaceutical or biotechnology industry classification, less a reviewed exclusion list of contract research organisations, device and diagnostics makers and diversified generics manufacturers.
  • An asset attributed to three or more different companies is treated as shared standard of care rather than any one company’s programme and excluded. Pembrolizumab alone appears under 21 tickers in raw trial data.
  • A programme counts only where at least one industry-sponsored trial supports it, so investigator-initiated academic studies of third-party drugs are excluded.

Allocated capital divides each company’s market capitalisation evenly across the indications it is running clinical programmes in, so every dollar of the universe is counted exactly once. Total market capitalisation competing counts a company in each of its indications and therefore sums to more than the universe.

Third-party market size estimates are not used anywhere on this page. Approved incumbents are excluded from competitor counts, and companies above $20B are outside the universe by construction.

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