Recent Updates
Recently added Catalysts

Constipation Predominant Irritable Bowel Syndrome: one US-listed biotech with a clinical-stage programme

Rare Genetic & MetabolicUncontestedData as of 2026-09-04

Competitors1in the clinic
Median market cap$924Muniverse median $1.20B
Allocated capital$462M$924M competing
Phase 3 or filed10 mid, 0 early
Pure plays0this indication only
Capital rank209/299crowding rank 214

Constipation Predominant Irritable Bowel Syndrome is uncontested. Ardelyx (ARDX) is the only US-listed developer in the $100M to $20B band running a clinical programme here, with Tenapanor in phase 3.

There is no public comparable to price it against. ARDX spreads its $924M market cap across 2 indications, so $462M of it is allocated here.

The one programme here is in late-stage development, but it carries no dated catalyst in the next 12 months.

$462M of allocated capital sits in Constipation Predominant Irritable Bowel Syndrome, ranking it 209th of 299 indications by the money committed to it.

Companies developing drugs for Constipation Predominant Irritable Bowel Syndrome 1

TickerCompanyLead assetPhaseTrialsMarket capPure playIndicationsNext catalyst
ARDXArdelyxTenapanorPhase 32$924MNo2 31 Dec 2027

Sorted by phase, then by market capitalisation. Ticker links open the company profile.

Why Constipation Predominant Irritable Bowel Syndrome counts as uncontested

Uncontested. One US-listed developer in the size band is running a clinical programme here, so there is no public comparable to price it against.

The map splits indications on two folds: six or more competitors counts as crowded, and a median company above $1.20B counts as richly priced. Constipation Predominant Irritable Bowel Syndrome has one competitor and a median of $924M.

Rare Genetic & Metabolic

Rare Genetic & Metabolic holds $103B of the map's capital, 15.3% of the total, spread across 32 indications and 48 companies. 10 of those indications have more than one company competing.

See every Rare Genetic & Metabolic indication on the map

Related indications in Rare Genetic & Metabolic

Paroxysmal Nocturnal Hemoglobinuria1 company · $461M · median $1.4BUncontestedGuillain-Barré Syndrome1 company · $459M · median $918MUncontestedOsteogenesis Imperfecta Type IV1 company · $488M · median $1.5BUncontestedEpidermolysis Bullosa Dystrophica1 company · $339M · median $339MUncontestedTransfusion Dependent Beta-thalassemia1 company · $330M · median $2.0BUncontestedPyruvate Kinase Deficiency1 company · $330M · median $2.0BUncontestedThalassemia1 company · $330M · median $2.0BUncontestedErythropoietic Protoporphyria1 company · $609M · median $3.0BUncontested

Constipation Predominant Irritable Bowel Syndrome pipeline questions

Which biotech companies are developing drugs for Constipation Predominant Irritable Bowel Syndrome?

Ardelyx (ARDX, Tenapanor, Phase 3). Those are the 1 US-listed developer in the $100M to $20B market cap band with a clinical-stage programme in Constipation Predominant Irritable Bowel Syndrome.

How advanced is the Constipation Predominant Irritable Bowel Syndrome pipeline?

Of the 1 clinical-stage programme in Constipation Predominant Irritable Bowel Syndrome, 1 is in Phase 3 or filed, 0 are in mid-stage development and 0 are in early-stage development.

Is anyone else developing a drug for Constipation Predominant Irritable Bowel Syndrome?

No. ARDX is the only US-listed company in the $100M to $20B market cap band with a clinical-stage programme in Constipation Predominant Irritable Bowel Syndrome, which is why the indication is classified as uncontested.

How this page is built

  • Universe is US-listed drug developers with a $100M to $20B market capitalisation, identified by SEC SIC code 2833, 2834 or 2836 or by a pharmaceutical or biotechnology industry classification, less a reviewed exclusion list of contract research organisations, device and diagnostics makers and diversified generics manufacturers.
  • An asset attributed to three or more different companies is treated as shared standard of care rather than any one company’s programme and excluded. Pembrolizumab alone appears under 21 tickers in raw trial data.
  • A programme counts only where at least one industry-sponsored trial supports it, so investigator-initiated academic studies of third-party drugs are excluded.

Allocated capital divides each company’s market capitalisation evenly across the indications it is running clinical programmes in, so every dollar of the universe is counted exactly once. Total market capitalisation competing counts a company in each of its indications and therefore sums to more than the universe.

Third-party market size estimates are not used anywhere on this page. Approved incumbents are excluded from competitor counts, and companies above $20B are outside the universe by construction.

Back to the disease map