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ZL-3101

Phase 2

Eczema | Small molecule | Dermatology |Zai Lab Limited|Last Updated: Jan 24, 2019

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment290

FDA Designations

No designations recorded

Clinical trial landscape

ZL-3101 · 1 trial · 1 indication

Phase 2 1
NCT03134352Study to Evaluate the Efficacy and Safety of ZL-3101 in Subjects With Subacute EczemaEczema
COMPLETED290 Analytics
PHASE2COMPLETED
Study to Evaluate the Efficacy and Safety of ZL-3101 in Subjects With Subacute Eczema
EczemaUnlock trial analytics

Study Endpoints

Primary Endpoints

Eczema Area and Severity Index (EASI) score changes from baseline to day 21
21 days

To evaluate efficacy of Fugan ointment applied to involved skin of subjects with mild to moderate subacute eczema

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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ZL-3101(Fugan) bid groupEXPERIMENTALFugan AM + Fugan PM
ZL-3101(Fugan) qd groupEXPERIMENTALFugan AM + Placebo PM
placebo groupPLACEBO_COMPARATORPlacebo AM + Placebo PM

Interventions

NameTypeDescription
ZL-3101DRUGA brown ointment, 10g/tube, 0.4g herb/g ointment, Topical
PlaceboDRUGA brown ointment, 10g/tube, 0.02 g herb/g ointment (5% of Fugan active ointment), Topical
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: 1. Male or female subjects between 18 and 65 years of age inclusive, at the time of signing the informed consent; from outpatient clinic; 2. Subjects with a diagnosis of subacute eczema (Zhao 2001). Subacute eczema is often developed from improperly treated acute eczema or a few...

Countries:China
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Frequently asked questions about ZL-3101

What is ZL-3101 used for?

ZL-3101 is an investigational small molecule being developed for the treatment of eczema, also known as subacute eczema. It is currently in Phase 2 clinical development and has not been approved by regulatory authorities. The drug is being studied for its efficacy and safety in patients with this skin condition.

Who makes ZL-3101?

ZL-3101 is being developed by Zai Lab Limited, a biopharmaceutical company traded on the NASDAQ under the ticker symbol ZLAB. The company is conducting clinical research on this investigational small molecule for the treatment of eczema.

What phase is ZL-3101 in?

ZL-3101 is in Phase 2 clinical development. A Phase 2 clinical trial evaluating the drug in patients with subacute eczema has been completed. The drug is investigational and has not received regulatory approval for any use.

What clinical trials is ZL-3101 in?

ZL-3101 has one completed Phase 2 clinical trial, identified as NCT03134352, titled "Study to Evaluate the Efficacy and Safety of ZL-3101 in Subjects With Subacute Eczema." This randomized, double-blind, placebo-controlled trial enrolled 290 participants in China.

Is ZL-3101 FDA approved?

No, ZL-3101 is not FDA approved. It is an investigational drug currently in Phase 2 clinical development for the treatment of eczema. The drug has not completed the clinical trial process required for regulatory approval and remains under investigation.