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Saroglitazar Magnesium

Phase 3

Primary Biliary Cholangitis | Small molecule | Gastrointestinal |cbdMD, Inc.|Last Updated: May 12, 2026

Target and mechanism

Molecular targetPPARA, PPARG
Target classAgonist
ModalitySmall molecule

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment102

FDA Designations

No designations recorded

Clinical trial landscape

Saroglitazar Magnesium · 1 trial · 1 indication

Phase 3 1
NCT06427395Open-Label Extension Study of Saroglitazar Magnesium in Participants With Primary Biliary CholangitisPrimary Biliary Cholangitis
ACTIVE NOT_RECRUITING102 Analytics
PHASE3ACTIVE NOT_RECRUITING
Open-Label Extension Study of Saroglitazar Magnesium in Participants With Primary Biliary Cholangitis
Primary Biliary CholangitisUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of participants with treatment-related adverse events as assessed by CTCAE v5.0
From baseline to 24 Months/EOT

Secondary Endpoints

Proportion of participants achieving biochemical response based on the composite endpoints of ALP and total bilirubin
From baseline to Months 12 and 24/EOT
Proportion of participants with biochemical response based on the composite endpoints of ALP and total bilirubin
From baseline to Months 12 and 24/EOT
Time to occurrence of the clinical outcome events in study participants with PBC
From baseline to 24 Months/EOT
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Saroglitazar Magnesium 1 mgEXPERIMENTALSaroglitazar Magnesium 1 mg tablet orally administered once daily in the morning before breakfast without food, for the duration of treatment (24 months).

Interventions

NameTypeDescription
Saroglitazar Magnesium 1 mgDRUGSaroglitazar Magnesium 1 mg will be assigned to all participants enrolled in the open label extension program
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites28

Inclusion Criteria: 1. Must provide written informed consent and agree to comply with the trial protocol 2. Participated and completed SARO.21.001, the double-blind treatment phase study Exclusion Criteria: 1. Consumption of 2 standard drinks per day if male and 1 standard drink per day if female...

Countries:United StatesArgentinaTurkey (Türkiye)
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Frequently asked questions about Saroglitazar Magnesium

What is Saroglitazar Magnesium used for?

Saroglitazar Magnesium is an investigational small molecule being developed for Primary Biliary Cholangitis, a chronic liver disease. It is currently in Phase 3 clinical development and has not been approved by regulatory authorities. The drug is being studied in patients with this condition to evaluate its safety and efficacy.

Who makes Saroglitazar Magnesium?

Saroglitazar Magnesium is being developed by cbdMD, Inc., a company traded on the stock exchange under the ticker YCBD. The company is conducting clinical trials to evaluate the drug for the treatment of Primary Biliary Cholangitis.

What phase is Saroglitazar Magnesium in?

Saroglitazar Magnesium is in Phase 3 clinical development. It is an investigational drug, meaning it has not yet been approved by regulatory agencies. The ongoing Phase 3 trial is an open-label extension study designed to assess the long-term effects of the drug in patients with Primary Biliary Cholangitis.

What clinical trials is Saroglitazar Magnesium in?

Saroglitazar Magnesium is being studied in a Phase 3 open-label extension trial with the identifier NCT06427395. This trial enrolls approximately 102 participants with Primary Biliary Cholangitis and is active but not recruiting. The study is being conducted in the United States, Argentina, and Turkey.

Is Saroglitazar Magnesium the same as Saroglitazar Magnesium 1 mg?

Yes, Saroglitazar Magnesium is also known as Saroglitazar Magnesium 1 mg. Both names refer to the same investigational drug being developed for Primary Biliary Cholangitis. The 1 mg designation indicates the dosage strength used in clinical studies.