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CSTI-500

Phase 1

Prader-Willi Syndrome | Small molecule | Rare Disease |cbdMD, Inc.|Last Updated: Aug 9, 2023

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment10

FDA Designations

No designations recorded

Clinical trial landscape

CSTI-500 · 1 trial · 1 indication

Phase 1 1
NCT05504395A Pharmacokinetic and Safety Study of CSTI-500 in Subjects With Prader-Willi SyndromePrader-Willi Syndrome
COMPLETED10 Analytics
PHASE1COMPLETED
A Pharmacokinetic and Safety Study of CSTI-500 in Subjects With Prader-Willi Syndrome
Prader-Willi SyndromeUnlock trial analytics

Study Endpoints

Primary Endpoints

Maximum Observed Plasma Concentration (Cmax)
Pre-dose to 1, 2, 4, 8, 12, 24, 48, 72, and 144 hours post-dose

Maximum observed plasma concentration following drug administration determined directly from the concentration-time profile.

AUC0-72
Pre-dose to 1, 2, 4, 8, 12, 24, 48, and 72 hours post-dose

Area under the plasma-drug concentration-time curve from pre-dose (time 0) to 72 hours after drug administration

AUC0-inf
Pre-dose to 1, 2, 4, 8, 12, 24, 48, 72, and 144 hours post-dose

Area under the plasma-drug concentration-time curve from pre-dose (time 0) extrapolated to infinite time

CSTI-500 plasma concentration
1 hour post-dose

Secondary Endpoints

Incidence of treatment-emergent adverse events (TEAEs)
From pre-dose to 15 days post-dose
Incidence of clinically significant findings in physical examinations
Screening to 12, 24, 48, 72, and 144 hours post-dose
Incidence of clinically significant findings in vital signs
Screening and pre-dose to 1, 2, 4, 8, 12, 24, 48, 72, and 144 hours post-dose
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeOTHER

Treatment Arms

ArmTypeDescription
CSTI-500 10mgEXPERIMENTALAll eligible subjects will be administered a single oral dose of CSTI-500 10 mg at Visit 2

Interventions

NameTypeDescription
CSTI-500DRUGSingle 10 mg capsule
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Eligibility Criteria

Age Range13 Years to 50 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Male and female subjects (13-50 years of age at screening) with a documented medical record history of PWS confirmed by genetic testing. * Subject must have a reliable caregiver/parent to bring the subject to the site for the visits, remain with the subject during visit times ...

Countries:United States
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Frequently asked questions about CSTI-500

What is CSTI-500 used for?

CSTI-500 is an investigational small molecule being developed for the treatment of Prader-Willi syndrome, a rare genetic disorder. It is currently in Phase 1 clinical development and has not been approved by the FDA.

Who makes CSTI-500?

CSTI-500 is being developed by cbdMD, Inc., a company traded on the NYSE American under the ticker symbol YCBD. The drug is currently in Phase 1 clinical development for Prader-Willi syndrome.

What phase is CSTI-500 in?

CSTI-500 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. A Phase 1 study of CSTI-500 in subjects with Prader-Willi syndrome has been completed.

What clinical trials is CSTI-500 in?

CSTI-500 has one completed Phase 1 clinical trial, identified as NCT05504395, titled 'A Pharmacokinetic and Safety Study of CSTI-500 in Subjects With Prader-Willi Syndrome.' The study enrolled 10 participants in the United States and was not randomized or double-blinded.

Is CSTI-500 the same as any other drug?

CSTI-500 is the primary name for this investigational drug. No alternative names have been reported for this compound in clinical development.