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G-Pump

Phase 2

Hypoglycemia | Small molecule | Other |Xeris Biopharma Holdings, Inc.|Last Updated: Oct 30, 2018

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment8
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02733588Delivery of G-Pump™ (Glucagon Infusion) From an OmniPod® to Prevent Hypoglycemia in Post-Bariatric Surgery PatientsPHASE2 COMPLETED 8Mar 1, 2016Jun 1, 2017Oct 30, 20181 United States
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Study Endpoints
Primary Endpoints
Detection/Notification of Hypoglycemia
0 - 120 minutes following dosing

Frequency with which the device controller software correctly identifies impending hypoglycemia (glucose \< 75 mg/dl) and notifies the investigator to initiate treatment. Reported as the number of successful identifications.

Secondary Endpoints
Number of Subjects With Severe Hypoglycemia
0 - 120 minutes following dosing
Number of Subjects With Rebound Hyperglycemia
0 - 120 minutes following dosing
Glucose Time in Range
0 - 120 minutes following dosing
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
G-Pump™ (glucagon infusion)EXPERIMENTAL0.15 or 0.3 mg G-Pump™ (glucagon infusion) administered from OmniPod® pump
Interventions
NameTypeDescription
G-Pump™ (glucagon infusion)DRUG0.15 or 0.3 mg G-Pump™ (glucagon infusion) administered from OmniPod® pump
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * diagnosed with ongoing post-bariatric hypoglycemia with prior episodes of neuroglycopenia, unresponsive to dietary intervention (low glycemic index, controlled carbohydrate portions) and trial of acarbose therapy at the maximally tolerated dose. * willingness to provide inform...

Countries:United States
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