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Valacyclovir

Phase 1

Healthy | Small molecule | Other |Viatris Inc.|Last Updated: Apr 23, 2024

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials3
Total Enrollment120

FDA Designations

No designations recorded

Clinical trial landscape

Valacyclovir · 3 trials · 1 indication

Phase 1 3
NCT00650494Fed Study of Valacyclovir Hydrochloride Tablets 1000 mg and Valtrex® Tablets 1000 mgHealthy
COMPLETED66 Analytics
NCT00649870Food Study of Valacyclovir Hydrochloride Tablets 1000 mg to Valtrex® Tablets 1000 mgHealthy
COMPLETED26 Analytics
NCT00649974Fasting Study of Valacyclovir Hydrochloride Tablets 1000 mg and Valtrex® Tablets 1000 mgHealthy
COMPLETED28 Analytics
PHASE1COMPLETED
Fed Study of Valacyclovir Hydrochloride Tablets 1000 mg and Valtrex® Tablets 1000 mg
HealthyUnlock trial analytics
PHASE1COMPLETED
Food Study of Valacyclovir Hydrochloride Tablets 1000 mg to Valtrex® Tablets 1000 mg
HealthyUnlock trial analytics
PHASE1COMPLETED
Fasting Study of Valacyclovir Hydrochloride Tablets 1000 mg and Valtrex® Tablets 1000 mg
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Bioequivalence
within 30 days
The 90% confidence interval for the LSMeans ratio of CPEAK, AUCL, and AUCI for the test and reference product should be between 80.00% and 125.00% for the natural log-transformed data.
blood collections through 24 hours
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeOTHER

Treatment Arms

ArmTypeDescription
1EXPERIMENTALValacyclovir Hydrochloride Tablets 1000mg
2ACTIVE_COMPARATORValtrex® Tablets 1000 mg

Interventions

NameTypeDescription
Valacyclovir Hydrochloride Tablets 1000mgDRUG1000mg, single dose fed
Valtrex® 1000 mgDRUG1000mg, single dose fed
Valacyclovir Hydrochloride Tablets 1000 mgDRUG1000mg, single dose fed
Valtrex® Tablets 1000 mgDRUG1000mg, single dose fed
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Age: 18 years and older. 2. Sex: Male and/or non-pregnant, non-lactating female. 1. Women of childbearing potential must have negative serum beta human chorionic gonadotropin (beta-HCG) pregnancy tests performed within 21 days prior to the start of the study and on the ev...

Countries:United States
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Frequently asked questions about Valacyclovir

What is Valacyclovir used for?

Valacyclovir is an investigational small molecule being studied in healthy volunteers. It is in Phase 1 clinical development, with completed trials evaluating the drug in healthy adult participants. The drug is being developed by Viatris Inc. (VTRS).

Who makes Valacyclovir?

Valacyclovir is being developed by Viatris Inc., a biopharmaceutical company traded on the NASDAQ under the ticker VTRS. The company is conducting Phase 1 clinical trials of the drug in the United States.

What phase is Valacyclovir in?

Valacyclovir is in Phase 1 clinical development. Three Phase 1 trials have been completed, all enrolling healthy volunteers. The drug is investigational and has not been approved by the FDA.

What clinical trials is Valacyclovir in?

Valacyclovir has been studied in three completed Phase 1 trials: NCT00649870, NCT00649974, and NCT00650494. These trials evaluated the drug in healthy volunteers in the United States, with enrollments of 26, 28, and 66 participants respectively.

Is Valacyclovir the same as Valtrex?

Valacyclovir is being studied in trials that compare it to Valtrex tablets. The trials are designed to evaluate the pharmacokinetics of Valacyclovir hydrochloride tablets 1000 mg relative to Valtrex tablets 1000 mg under fasting and fed conditions.