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Topamax Sprinkle

Phase 1

Healthy | Small molecule | Other |Viatris Inc.|Last Updated: Apr 23, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials3
Total Enrollment107
FDA Designations
No designations recorded
Clinical Trials (3)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00648934Fed Study of Topiramate Sprinkle Capsules 25 mg and Topamax® Sprinkle Capsules 25 mgPHASE1 COMPLETED 36Nov 1, 2005Dec 1, 2005Apr 23, 20241 United States
NCT00649467Applesauce Study of Topiramate Sprinkle Capsules 25 mg and Topamax® Sprinkle Capsules 25 mgPHASE1 COMPLETED 35Nov 1, 2005Dec 1, 2005Apr 23, 20241 United States
NCT00649740Fasting Study of Topiramate Sprinkle Capsules 25 mg and Topamax® Sprinkle Capsules 25 mgPHASE1 COMPLETED 36Nov 1, 2005Dec 1, 2005Apr 23, 20241 United States
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Study Endpoints
Primary Endpoints
The 90% confidence interval for the LSMeans ratio of CPEAK, AUCL, and AUCI for the test and reference product should be between 80.00% and 125.00% for the natural log-transformed data.
blood collections through 144 hours
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeOTHER
Treatment Arms
ArmTypeDescription
1EXPERIMENTALTopiramate Sprinkle Capsules 25 mg
2ACTIVE_COMPARATORTopamax® Sprinkle Capsules 25 mg
Interventions
NameTypeDescription
Topiramate Sprinkle Capsules 25 mgDRUG25mg, single dose fed
Topamax® Sprinkle Capsules 25 mgDRUG25mg, single dose fed
Topamax® Sprinkle Capsule 25 mgDRUG25mg, single dose fasting
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * healthy, adult subjects, 18 years and older * able to swallow medication Exclusion Criteria: * institutionalized subjects * history of any significant disease * use of any prescription or OTC medications within 14 days of start of study * received any investigational product...

Countries:United States
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