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Synthroid

Phase 1

Healthy | Small molecule | Other |Viatris Inc.|Last Updated: Apr 24, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment65
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00648882Fasting Study of Levothyroxine Sodium Tablets 300 mcg to Synthroid® Tablets 300 mcgPHASE1 COMPLETED 33Mar 1, 2007May 1, 2007Apr 24, 20241 United States
NCT00648557Fasting Study of Levothyroxine Sodium Tablets 200 mg to Synthroid Tablets 200 mgPHASE1 COMPLETED 32Jan 1, 2003Mar 1, 2003Apr 24, 20241 United States
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Study Endpoints
Primary Endpoints
Bioequivalence
within 30 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeOTHER
Treatment Arms
ArmTypeDescription
1EXPERIMENTALLEVOTHYROXINE SODIUM TABLETS,USP 300 mcg;
2ACTIVE_COMPARATORSYNTHROID® 300 mcg Tablets
Interventions
NameTypeDescription
LEVOTHYROXINE SODIUM TABLETS,DRUG2x300mcg, single dose fasting
SYNTHROID® 300 mcg TabletsDRUG2x300mcg, single dose fasting
Levothyroxine Sodium Tablets 200 mgDRUG3x200mcg, single dose fasting
Synthroid Tablets 200 mgDRUG3x200mcg, single dose fasting
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Eligibility Criteria
Age Range18 Years — 50 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Age: 18-50 years. 2. Sex: Men and/or non-pregnant, non-lactating women. 1. Women of childbearing potential must have negative serum β human chorionic gonadotropin (HCG) pregnancy tests performed within 14 days prior to of the study and on the evening prior to each dose ad...

Countries:United States
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