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Mylan's insulin glargine

Phase 3

Type 1 Diabetes Mellitus | Small molecule | Metabolic |Viatris Inc.|Last Updated: Mar 3, 2022

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment127
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02666430Extension Study to Assess Safety and Efficacy of Mylan's Insulin Glargine and Lantus® in Type 1 Diabetes Mellitus (T1DM) PatientsPHASE3 COMPLETED 127Dec 1, 2015Jul 1, 2017Mar 3, 202281 United States, Canada +6
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Study Endpoints
Primary Endpoints
Change in Hemoglobin A1c (HbA1c) From Baseline
Baseline to 36 weeks
Secondary Endpoints
Change From Baseline in Fasting Plasma Glucose
Baseline to 36 weeks
Overall Average of Self-monitoring Blood Glucose (SMBG) Change From Baseline
Baseline to 36 weeks
Change From Baseline Total Daily Insulin Dose
Baseline to 36 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Mylan's insulin glargineEXPERIMENTALPatients will be administered either Mylan insulin glargine or Lantus® subcutaneously, once daily in combination with lispro and titrated based on blood glucose readings per standard of care for a total of thirty-six (36) weeks, split into three cycles of twelve (12) weeks each.
Lantus®ACTIVE_COMPARATORPatients will be administered either Mylan insulin glargine or Lantus® subcutaneously, once daily in combination with lispro and titrated based on blood glucose readings per standard of care for a total of thirty-six (36) weeks, split into three cycles of twelve (12) weeks each.
Interventions
NameTypeDescription
Mylan's insulin glargineDRUG -
Lantus®DRUG -
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Eligibility Criteria
Age Range18 Years — 66 Years
SexALL
Healthy VolunteersYes
Study Sites81

Inclusion Criteria: 1. Patients who have completed the 52-week treatment period (irrespective of their age at the completion of MYL-GAI-3001 trial) of the MYL-GAI-3001 trial and were assigned to Lantus® in that study. 2. Patients or their legal representatives must give written and signed informed ...

Countries:United StatesCanadaCzechiaEstoniaGermanyHungaryLatviaSlovakia
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