Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Metoprolol · 4 trials · 1 indication
| Arm | Type | Description |
|---|---|---|
| 1 | EXPERIMENTAL | Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg |
| 2 | ACTIVE_COMPARATOR | Lopressor HCT® Tablets 100/50 mg |
| Name | Type | Description |
|---|---|---|
| Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg | DRUG | 100/50mg, single dose fed |
| Lopressor HCT® Tablets 100/50 mg | DRUG | 100/50mg, single dose fed |
| Metoprolol Tartrate Tablets 25 mg | DRUG | 2x50mg, single dose fed |
| Lopressor® Tablets 50 mg | DRUG | 1x50mg, single dose fed |
| Metoprolol Tartrate Tablets 100 mg | DRUG | 100mg, single dose fed |
| Lopressor® Tablets 100 mg | DRUG | 100mg, single dose fed |
Inclusion Criteria: 1. Age: 18 years and older. 2. Sex: Male and non-pregnant, non-lactating female 1. Women of childbearing potential must have negative serum Beta-human chorionic gonadotropin (HCG) pregnancy tests performed within 14 days prior to the start of the study and the evening prior ...
Metoprolol is a small molecule drug developed by Viatris Inc. (ticker VTRS). It is an antagonist of ADRB1, also known as the beta-1 adrenergic receptor. The drug has been studied in Phase 1 clinical trials, with four completed trials involving a total of 103 healthy volunteers.
Metoprolol targets ADRB1, the beta-1 adrenergic receptor. It acts as an antagonist at this receptor. By blocking ADRB1, metoprolol interferes with the binding of catecholamines such as epinephrine and norepinephrine, which are involved in regulating heart rate and blood pressure.
Metoprolol is developed by Viatris Inc., which trades under the ticker symbol VTRS. Viatris is the company responsible for the clinical development of the metoprolol formulations described in these trials.
Metoprolol is in Phase 1 clinical development. Four Phase 1 trials have been completed, and there are currently no active trials. The completed trials enrolled a total of 103 participants. The drug is investigational and has not been approved by the FDA for any indication based on the available information.
Metoprolol has been studied in four completed Phase 1 trials: NCT00649688, NCT00649233, NCT00649116, and NCT00648271. These trials evaluated metoprolol tartrate and metoprolol tartrate/hydrochlorothiazide tablets in healthy volunteers under fasting and fed conditions, with enrollment ranging from 19 to 32 participants per trial.