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MYL-1601D Product

Phase 3

Diabetes Mellitus, Type 1 | Small molecule | Metabolic |Viatris Inc.|Last Updated: Feb 25, 2022

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedACTIVE_CONTROLLED
Total Trials1
Total Enrollment478
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03760068Mylan Insulin Aspart StudyPHASE3 COMPLETED 478Nov 7, 2018Jan 17, 2020Feb 25, 2022158 United States
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Study Endpoints
Primary Endpoints
Treatment Emergent Antibody Response (TEAR)
Baseline to week 24

The number of subjects who were TEAR positive. TEAR is defined as either one of the following: 1. Subjects who are Anti-Drug Antibody (ADA) negative at baseline and become positive at any timepoint post baseline 2. Subjects who are ADA positive at baseline and demonstrate 4-fold increase in titer values at any timepoint post baseline visit.

Secondary Endpoints
Change in HbA1c From Baseline
Baseline to week 24
Change in Fasting Plasma Glucose From Baseline
Baseline to week 24
Change in Prandial Insulin Dose From Baseline
Baseline to week 24
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
MYL-1601D Product (100 U/mL)ACTIVE_COMPARATOR -
FlexPen NovoLog® (100 U/mL)ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
MYL-1601D ProductDRUG(100 U/mL)
FlexPen NovoLog®DRUG(100 U/mL)
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites158

Inclusion criteria 1. Written and signed informed consent. 2. Clinical diagnosis of type 1 diabetes mellitus for at least 6 months prior to screening. 3. Subject is able and willing to comply with the requirements of the study protocol. Exclusion Criteria 1. History or presence of a medical condi...

Countries:United States
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