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MYL-1501D product using manufacture process V

Phase 3

Diabetes Mellitus, Type 1 | Small molecule | Metabolic |Viatris Inc.|Last Updated: Mar 3, 2022

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment219
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03376789Mylan Insulin Glargine StudyPHASE3 COMPLETED 219Nov 29, 2017Jan 10, 2019Mar 3, 202238 United States
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Study Endpoints
Primary Endpoints
Change in HbA1c
Baseline to Week 18

Change in HbA1c from baseline

Secondary Endpoints
Change in FPG
Baseline to Week 18
Change in Insulin Dose
Baseline to Week 18
Change in 8-point SMBG
Baseline to Week 18
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
MYL-1501D (Process V Product)ACTIVE_COMPARATORMYL-1501D (Process V Product)
MYL-1501D (Process VI Product)ACTIVE_COMPARATORMYL-1501D (Process VI Product)
Interventions
NameTypeDescription
MYL-1501D product using manufacture process VDRUGMYL-1501D product using manufacture process V
MYL-1501D product using manufacture process VIDRUGMYL-1501D product using manufacture process VI
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites38

Inclusion Criteria: 1. Written and signed informed consent needs to be provided by subjects or their legal representatives before starting any protocol-specific procedures. 2. Male and female subjects between the ages of 18 to 65 years, both ages inclusive. 3. Subjects with an established diagnosis...

Countries:United States
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