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Econazole Nitrate, 1%

Phase 3

Tinea Pedis | Small molecule | Infectious Disease |Viatris Inc.|Last Updated: Mar 7, 2022

Target and mechanism

ModalitySmall molecule

Also known as Econazole Nitrate Cream, 1%

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment876

FDA Designations

No designations recorded

Clinical trial landscape

Econazole Nitrate, 1% · 1 trial · 1 indication

Phase 3 1
NCT03129321Therapeutic Equivalence and Safety of Two Econazole Nitrate Cream, 1% Products in Tinea PedisTinea Pedis
COMPLETED876 Analytics
PHASE3COMPLETED
Therapeutic Equivalence and Safety of Two Econazole Nitrate Cream, 1% Products in Tinea Pedis
Tinea PedisUnlock trial analytics

Study Endpoints

Primary Endpoints

Proportion of Patients in Each Active Treatment Group Who Are Considered a Therapeutic Cure
Day 42

To be considered a Therapeutic Cure, the patient must have both Clinical Cure (patient's total severity score must be ≤ 2 with no individual severity score \> 1) and Mycological Cure (patient must have a negative KOH test and a negative fungal culture) of tinea pedis

Proportion of Patients in Each Treatment Group Who Are Considered a Therapeutic Cure
Day 42

To be considered a Therapeutic Cure, the patient must have both Clinical Cure (patient's total severity score must be ≤ 2 with no individual severity score \> 1) and Mycological Cure (patient must have a negative KOH test and a negative fungal culture) of tinea pedis

Secondary Endpoints

Proportion of Patients in Each Active Treatment Group Who Are Considered a Clinical Cure (Patient's Total Severity Score Must be ≤ 2 With no Individual Severity Score > 1)
Day 42
Proportion of Patients in Each Active Treatment Group Who Are Considered a Mycological Cure
Day 42
Proportion of Patients in Each Treatment Group Who Are Considered a Clinical Cure (Patient's Total Severity Score Must be ≤ 2 With no Individual Severity Score > 1)
Day 42
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
TestEXPERIMENTALEconazole Nitrate Cream, 1%, topical, sufficient amount to cover all affected areas on the feet once daily for 28 days
Reference StandardACTIVE_COMPARATOREconazole Nitrate Cream, 1%, topical, sufficient amount to cover all affected areas on the feet once daily for 28 days
PlaceboPLACEBO_COMPARATORPlacebo Cream, topical, sufficient amount to cover all affected areas on the feet once daily for 28 days

Interventions

NameTypeDescription
Econazole Nitrate Cream, 1%DRUG -
PlaceboDRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Healthy male or non-pregnant, non-lactating female ≥ 18 years of age. * Clinical diagnosis of tinea pedis with lesions localized to the interdigital spaces or predominantly interdigital, but may extend to other areas of the foot (the non-interdigital lesions should not be hype...

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Frequently asked questions about Econazole Nitrate, 1%

What is Econazole Nitrate, 1% used for?

Econazole Nitrate, 1% is a topical cream being developed for the treatment of tinea pedis, commonly known as athlete's foot. It is an antifungal product in the infectious disease therapeutic area. The cream is applied to the affected skin area.

Who makes Econazole Nitrate Cream, 1%?

Econazole Nitrate Cream, 1% is developed by Viatris Inc., which trades under the ticker symbol VTRS. Viatris is the company responsible for the development and regulatory submission of this topical antifungal product.

What phase is Econazole Nitrate, 1% in?

Econazole Nitrate, 1% is in Phase 3 clinical development. The program includes one completed Phase 3 trial. It is an investigational product and has not been approved by the FDA for the treatment of tinea pedis.

What clinical trials is Econazole Nitrate, 1% in?

Econazole Nitrate, 1% has been studied in a completed Phase 3 trial, NCT03129321, titled Therapeutic Equivalence and Safety of Two Econazole Nitrate Cream, 1% Products in Tinea Pedis. The trial enrolled 876 participants and was randomized, double-blind, and placebo-controlled.

Is Econazole Nitrate, 1% the same as Econazole Nitrate Cream, 1%?

Yes, Econazole Nitrate, 1% and Econazole Nitrate Cream, 1% refer to the same product. The alternative name specifies the cream formulation. Both names are used interchangeably for the topical antifungal developed by Viatris Inc. for tinea pedis.