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Divalproex

Phase 1

Healthy | Small molecule | Other |Viatris Inc.|Last Updated: Sep 25, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment78
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00647712Fasting Study of Divalproex Sodium Extended-Release Tablets 500 mg to Depakote ER® Tablets 500 mgPHASE1 COMPLETED 38Dec 1, 2004Dec 1, 2004Sep 25, 20091 United States
NCT00648076Food Study of Divalproex Sodium Extended-Release Tablets 500 mg to Depakote ER® Tablets 500 mgPHASE1 COMPLETED 40Dec 1, 2004Dec 1, 2004Sep 25, 20091 United States
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Study Endpoints
Primary Endpoints
Bioequivalence
within 30 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
1EXPERIMENTALDivalproex Sodium Extended-Release Tablets 500 mg
2ACTIVE_COMPARATORDepakote ER® Tablets 500 mg
Interventions
NameTypeDescription
Divalproex Sodium Extended-Release Tablets 500 mgDRUG500mg, single dose fasting
Depakote ER® Tablets 500 mgDRUG500mg, single dose fasting
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Eligibility Criteria
Age Range18 Years — N/A
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Age: 18 years and older. 2. Sex: Male. 3. Weight: At least 60 kg (132 lbs) and within 15% of Ideal Body Weight (IBW), as referenced by the Table of "Desirable Weights of Adults" Metropolitan Life Insurance Company, 1999 (See Part II ADMINISTRATIVE ASPECTS OF BIOEQUIVALENCE PR...

Countries:United States
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