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VX-950

Phase 2

Hepatitis C | Small molecule | Infectious Disease |Vertex Pharmaceuticals Incorporated|Last Updated: Dec 21, 2007

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials2
Total Enrollment32

FDA Designations

No designations recorded

Clinical trial landscape

VX-950 · 2 trials · 1 indication

Phase 2 1Phase 1 1
NCT00262483Phase 2 Study of VX-950, Pegasys and Copegus in Hepatitis CHepatitis C
COMPLETED12 Analytics
PHASE2COMPLETED
Phase 2 Study of VX-950, Pegasys and Copegus in Hepatitis C
Hepatitis CUnlock trial analytics

Study Endpoints

Primary Endpoints

Safety of triple combination therapy.
retrospective and prospective
Viral kinetics

Secondary Endpoints

Pharmacokinetics of VX-950, peginterferon alfa-2a and ribavirin.
retrospective and prospective
Plasma HCV RNA levels
retrospective and prospective
Assess the safety of VX-950 in combination with peginterferon
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP

Interventions

NameTypeDescription
VX-950DRUG -
ribavirinDRUG -
peginterferon alfa-2aDRUG -
peginterferonDRUG -
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: * Infected with hepatitis C virus Exclusion Criteria: * Contraindications to peginterferon or ribavirin therapy.

Countries:United StatesPuerto RicoGermanyNetherlands
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Competitive Landscape -Hepatitis C 11 trials

Frequently asked questions about VX-950

What is VX-950 used for?

VX-950 is an investigational small molecule being developed for the treatment of Hepatitis C. It is currently in Phase 2 clinical development and has not been approved by the FDA. The drug is being studied in combination with peginterferon and ribavirin for this infectious disease indication.

Who makes VX-950?

VX-950 is being developed by Vertex Pharmaceuticals Incorporated, a biopharmaceutical company traded on the NASDAQ under the ticker symbol VRTX. The company is conducting clinical trials to evaluate the drug's safety and efficacy in patients with Hepatitis C.

What phase is VX-950 in?

VX-950 is in Phase 2 clinical development for Hepatitis C. It is an investigational drug, meaning it has not yet received regulatory approval. Two clinical trials have been completed, including a Phase 1 and a Phase 2 study, with a total of 32 participants enrolled.

What clinical trials is VX-950 in?

VX-950 has been studied in two completed clinical trials. NCT00251199 was a Phase 1 study of VX-950 and peginterferon for Hepatitis C with 20 participants in Germany and the Netherlands. NCT00262483 was a Phase 2 study of VX-950, Pegasys and Copegus in Hepatitis C with 12 participants in the United States and Puerto Rico.

Is VX-950 the same as telaprevir?

VX-950 is the development code for the drug also known as telaprevir. It is a small molecule protease inhibitor being studied for Hepatitis C. The drug has been evaluated in clinical trials in combination with peginterferon and ribavirin, though it remains investigational and is not yet approved.