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VP-102 with applicator

Phase 2

Molluscum Contagiosum | Small molecule | Other |Verrica Pharmaceuticals Inc.|Last Updated: Aug 11, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment33
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03186378Evaluation of Systemic Exposure to VP-102 in Subjects With Molluscum Contagiosum.PHASE2 COMPLETED 33Jun 8, 2017Jun 25, 2018Aug 11, 20211 United States
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Study Endpoints
Primary Endpoints
The Presence or Absence of Systemic Exposure to Cantharidin by the Collection and Analysis of Plasma Samples From Patients With 21 or More Molluscum Lesions Following Treatment of VP-102.
24 hours

The primary objective is to determine any potential systemic exposure from a single 24-hour dermal application of VP-102 topical film-forming solution when applied to molluscum contagiosum (molluscum) lesions on pediatric subjects 2 years old and older.

Secondary Endpoints
Measurement of Efficacy - Complete Clearance
Baseline through EOS Day 84
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Exposure GroupEXPERIMENTALThis group is open label and allows for up to 16 subjects with 21 or more molluscum lesions will be enrolled. They must complete all blood draws or will be replaced. Intervention Drug: Subjects will receive treatment to their molluscum contagiosum lesions per protocol with VP-102 using the VP-102 applicator.
Standard GroupEXPERIMENTALThis group is open label allowing up to 16 subjects with 20 lesions or less to be enrolled. Drug: Subjects will receive treatment to their molluscum lesions with VP-102 using the VP-102 applicator.
Interventions
NameTypeDescription
VP-102 with applicatorCOMBINATION_PRODUCTSubjects will receive treatment to their molluscum contagiosum with VP-102.
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Eligibility Criteria
Age Range2 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: 1. Be healthy subjects ages 2 years and older. 2. Patients with 1-20 lesions may be enrolled and treated in the standard treatment group but are not eligible for the exposure study. 3. Patients with 21 or more lesions may only be enrolled in the exposure group. Subjects particip...

Countries:United States
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