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VP-102 Cantharidin film forming

Phase 2

Common Wart | Small molecule | Oncology |Verrica Pharmaceuticals Inc.|Last Updated: Nov 27, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment56
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03487549Cantharidin and Occlusion in Verruca EpitheliumPHASE2 COMPLETED 56Mar 27, 2018Jul 15, 2019Nov 27, 20245 United States
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Study Endpoints
Primary Endpoints
Cohort 1: Proportion of Subjects Exhibiting Complete Clearance of All Treatable Warts (Baseline and New) at the EOS Visit (Day 84)
Treatment Visit Day 1 (Baseline) compared to Day 84 (EOS) Visit.

Cohort 1: Proportion of subjects exhibiting complete clearance of all treatable warts (baseline and new) at the EOS Visit (Day 84).

Cohort 2: Proportion of Subjects Exhibiting Complete Clearance of All Treatable Warts (Baseline and New) at the EOT Visit (Day 84)
Compare Treatment Visit 1 (Baseline) to EOT Visit (Day 84)

Cohort 2: Proportion of subjects exhibiting complete clearance of all treatable warts (baseline and new) at the EOT Visit (Day 84).

Secondary Endpoints
Cohort 1: Change From Baseline in the Number of Treatable Warts (Baseline and New) at the EOS Visit (Day 84)
Change in the number of warts compared at Baseline (Visit 1) to the End of Study Visit (Day 84).
Cohort 1: Percent Change From Baseline in the Number of Treatable Warts (Baseline and New) at the EOT Visit (Day 84).
Baseline (Visit 1) to End of Treatment Visit (Day 84).
Cohort 1: Proportion of Subjects Exhibiting Complete Clearance of All Treatable Warts (Baseline and New) at Visit 2, Visit 3, Visit 4 and Over the Duration of the Study
Baseline, Day 14, 28, 42 and 84 (EOS)
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
VP-102EXPERIMENTALOpen label of VP-102 cantharidin topical film forming solution, using the VP-102 applicator.
Interventions
NameTypeDescription
VP-102 Cantharidin topical film forming solutionCOMBINATION_PRODUCTVP-102, a single-use drug device combination product containing (cantharidin) topical solution, 0.7% (w/v). Treatment interval of at least 14 days between treatments.
VP-102 Cantharidin, topical film forming solutionCOMBINATION_PRODUCTVP-102, a single-use drug device combination product containing (cantharidin) topical solution, 0.7% (w/v). Treatment interval of at least 21 days between treatments.
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Eligibility Criteria
Age Range2 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites5

Inclusion Criteria: 1. Be healthy, immunocompetent males or females at least 2 years of age and older for Cohort 1 and 12 years of age and older for Cohort 2. 2. Present with 1-6 common warts (verruca vulgaris) located anywhere on the body except for the following prohibited areas: the eye area (in...

Countries:United States
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