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Avelumab and Pepinemab

Phase 1/2

Metastatic Pancreatic Adenocarcinoma | Biologics | Oncology |Vaccinex, Inc.|Trials Updated: May 21, 2025

Avelumab and Pepinemab development status

Highest phase Phase 1/2
Registered trials 1 across 1 sponsor since Nov 2021

Avelumab and Pepinemab target and mechanism

Molecular targetCD274
Target classOther
ModalityBiologics

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment48

FDA Designations

No designations recorded

Avelumab and Pepinemab clinical trials

Avelumab and Pepinemab · 1 trial · 1 indication

Phase 1/2 1
NCT05102721Trial of Immunotherapy With Avelumab and Pepinemab As Second Line For Patients With Metastatic Pancreatic AdenocarcinomaMetastatic Pancreatic Adenocarcinoma
ACTIVE NOT_RECRUITING48 Analytics
PHASE1/PHASE2ACTIVE NOT_RECRUITING
Trial of Immunotherapy With Avelumab and Pepinemab As Second Line For Patients With Metastatic Pancreatic Adenocarcinoma
Metastatic Pancreatic AdenocarcinomaUnlock trial analytics

Study Endpoints

Primary Endpoints

Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
10 years

Measured by adverse event severity and quantity

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Study Design & Arms

AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ExperimentalEXPERIMENTALSingle arm, all patients serially enrolled to combination doses of Avelumab and Pepinemab

Interventions

NameTypeDescription
Avelumab and PepinemabDRUGIV Infusions every two weeks.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Patient or legally acceptable representative must be able to understand and willing to sign an IRB approved written informed consent document. * Patients must be 18 years or older * Patients must have histologically confirmed metastatic pancreatic adenocarcinoma. * Patients mu...

Countries:United States
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