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TOUR006 -

Phase 2

Chronic Kidney Diseases | Small molecule | Nephrology |Tourmaline Bio, Inc.|Last Updated: Feb 24, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment143
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06362759A Study to Evaluate TOUR006 in Patients With Chronic Kidney Disease and Elevated Hs-CRPPHASE2 COMPLETED 143May 15, 2024Dec 4, 2025Feb 24, 202638 United States
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Study Endpoints
Primary Endpoints
Evaluate the effects of TOUR006 compared with placebo on hs-CRP
90 days

Evaluates the change from baseline in hs-CRP comparing TOUR006 and placebo

Secondary Endpoints
Evaluate the effects of TOUR006 compared with placebo on hs-CRP
90 days
Evaluate the pharmacokinetics by measuring serum concentrations of TOUR006
Baseline through Day 365
Evaluate the safety and tolerability of TOUR006 in participants with elevated cardiovascular risk and CKD
365 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
TOUR006 - 50 MGEXPERIMENTAL50 mg administered subcutaneously at Day 1 and Day 90 (Placebo administered at 30, 60, 120, and 150 Day timepoints)
TOUR006 - 25 MGEXPERIMENTAL25 mg administered subcutaneously at Day 1 and Day 90 (Placebo administered at 30, 60, 120, and 150 Day timepoints)
TOUR006 - 15 MGEXPERIMENTAL15 mg administered subcutaneously at Days 1, 30, 60, 90, 120, and 150
PlaceboPLACEBO_COMPARATORAdministered subcutaneously at Days 1, 30, 60, 90, 120, and 150
Interventions
NameTypeDescription
TOUR006 - 50 MGDRUGTOUR006 50 MG
TOUR006 - 25 MGDRUGTOUR006 25 MG
TOUR006 - 15 MGDRUGTOUR006 15 MG
PlaceboOTHERPlacebo
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites38

Inclusion Criteria: * Age ≥18 years at time of ICF signature. * Serum hs-CRP level ≥2.0 mg/L and \<15 mg/L * Diagnosis of chronic kidney disease, eGFR ≥15 and \<60 mL/min/1.73 m2 or eGFR ≥60 mL/min/1.73m2 and UPCR\>200 mg/g * Received COVID-19 vaccine at least 30 days prior to the Screening visit, ...

Countries:United States
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