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XM17

Phase 1

Bioequivalence | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Nov 9, 2021

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Trial Design

RandomizedACTIVE_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment49

FDA Designations

No designations recorded

Clinical trial landscape

XM17 · 1 trial · 1 indication

Phase 1 1
NCT02592031Study to Compare the Bioavailability, Safety and Tolerability of XM17 in Healthy, Down Regulated Young WomenBioequivalence
COMPLETED49 Analytics
PHASE1COMPLETED
Study to Compare the Bioavailability, Safety and Tolerability of XM17 in Healthy, Down Regulated Young Women
BioequivalenceUnlock trial analytics

Study Endpoints

Primary Endpoints

Comparison of single dose pharmacokinetics (Cmax)
Pre-dose at -10 min, 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 24, 36, 48, 72, 96, 120, 144 and 168 hours post-dose

XM17 and Gonal-f® tested statistically for bioequivalence.

Comparison of single dose pharmacokinetics (AUC0-t)
Pre-dose at -10 min, 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 24, 36, 48, 72, 96, 120, 144 and 168 hours post-dose

XM17 and Gonal-f® tested statistically for bioequivalence.

Secondary Endpoints

Pharmacokinetics AUC0-∞
Pre-dose at -10 min, 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 24, 36, 48, 72, 96, 120, 144 and 168 hours post-dose
Pharmacokinetics AUC0-168h
Pre-dose at -10 min, 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 24, 36, 48, 72, 96, 120, 144 and 168 hours post-dose
Pharmacokinetics Cmax,obs
Pre-dose at -10 min, 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 24, 36, 48, 72, 96, 120, 144 and 168 hours post-dose
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
XM17EXPERIMENTALXM17 will be administered by 1 mL syringes in graduated steps of 0.01 mL.
Gonal-f®EXPERIMENTALGonal-f® will be provided in pens with integrated vials of 0.5 mL
Zoladex®ACTIVE_COMPARATORZoladex® 3.6 mg will be administered by subcutaneous injection

Interventions

NameTypeDescription
XM17DRUG300 IU corresponds to an injection volume of 0.5 mL.
Gonal-f®DRUG300 IU corresponds to an injection volume of 0.5 mL.
Zoladex®DRUG3.6 mg
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Eligibility Criteria

Age Range18 Years to 39 Years
SexFEMALE
Healthy VolunteersYes

Inclusion Criteria: * Having signed written informed consent * Healthy female subjects of any racial origin * 18-39 years at the time of screening * Body mass index (BMI) between 18-29 kg/m2 and a body weight of ≥ 50 kg * Use of oral contraceptives for contraceptive purposes only and not for regula...

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Frequently asked questions about XM17

What is XM17 used for?

XM17 is an investigational small molecule being studied for bioequivalence. It was evaluated in a Phase 1 clinical trial in healthy, down regulated young women to compare its bioavailability, safety, and tolerability. The drug is not approved and remains in clinical development.

Who makes XM17?

XM17 is being developed by Teva Pharmaceutical Industries Limited, which trades under the ticker TEVA. The company conducted a Phase 1 study of XM17 to assess its bioavailability, safety, and tolerability in healthy young women.

What phase is XM17 in?

XM17 is in Phase 1 clinical development. It has completed one Phase 1 trial, which was an active-controlled, randomized study in healthy female volunteers. The drug is investigational and has not been approved by regulatory authorities.

What clinical trials is XM17 in?

XM17 has one completed clinical trial, identified as NCT02592031. This Phase 1 study compared the bioavailability, safety, and tolerability of XM17 in healthy, down regulated young women. The trial enrolled 49 participants and was active-controlled.

Is XM17 the same as any other drug?

No alternative names for XM17 have been identified. The drug is known by the name XM17 in clinical development. It is being studied for bioequivalence purposes, and no other names have been associated with it in the available information.