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Valacyclovir

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Aug 21, 2024

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLED
Total Trials2
Total Enrollment96

FDA Designations

No designations recorded

Clinical trial landscape

Valacyclovir · 2 trials · 1 indication

Phase 1 2
NCT01149499Valacyclovir 1000 mg Tablet Under Fasting ConditionsHealthy
COMPLETED60 Analytics
NCT01149460Valacyclovir 1000 mg Tablet Under Fed ConditionsHealthy
COMPLETED36 Analytics
PHASE1COMPLETED
Valacyclovir 1000 mg Tablet Under Fasting Conditions
HealthyUnlock trial analytics
PHASE1COMPLETED
Valacyclovir 1000 mg Tablet Under Fed Conditions
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Cmax (maximum observed concentration of drug substance in plasma)
Blood samples collected over 16 hour period

Bioequivalence based on Cmax

AUC0-t (area under the concentration-time curve from time zero to time of last measurable concentration)
Blood samples collected over 16 hour period

Bioequivalence based on AUC0-t

AUC0-inf (area under the concentration-time curve from time zero to infinity)
Blood samples collected over 16 hour period

Bioequivalence based on AUC0-inf

Cmax (Maximum Observed Concentration of Drug Substance in Plasma) - Valacyclovir
Blood samples collected over 12 hour period

Bioequivalence based on Cmax

AUC0-t (Area Under the Concentration-time Curve From Time Zero to Time of Last Measurable Concentration) - Valacyclovir
Blood samples collected over 12 hour period

Bioequivalence based on AUC0-t

AUC0-inf (Area Under the Concentration-time Curve From Time Zero to Infinity) - Valacyclovir
Blood samples collected over 12 hour period

Bioequivalence based on AUC0-inf

Secondary Endpoints

Cmax (Maximum Observed Concentration of Drug Substance in Plasma) - Acyclovir
Blood samples collected over 24 hour period
AUC0-t (Area Under Concentration-time Curve From Time Zero to Time of Last Measurable Concentration) - Acyclovir
Blood samples collected over 24 hour period
AUC0-inf (Area Under the Concentration-time Curve From Time Zero to Infinity) - Acyclovir
Blood samples collected over 24 hour period
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER

Treatment Arms

ArmTypeDescription
ValacyclovirEXPERIMENTALTest 1000 mg Valacyclovir Tablet
ValtrexACTIVE_COMPARATORReference Listed 1000 mg Valtrex Tablet

Interventions

NameTypeDescription
ValacyclovirDRUG1000 mg Tablet
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria * Male or female, non-smokers, 18 years of age and older. * Capable of consent * BMI greater than or equal to 19.0 and less than or equal to 30.0 kg/m2 Exclusion Criteria Subjects to whom any of the following applies will be excluded from the study: * Clinically significant il...

Countries:United StatesCanada
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Frequently asked questions about Valacyclovir

What is Valacyclovir used for?

Valacyclovir is an investigational small molecule being studied in healthy volunteers. It is currently in Phase 1 clinical development, with two completed trials evaluating its pharmacokinetics under fed and fasting conditions. The drug is not approved for any indication and remains in early-stage clinical testing.

Who makes Valacyclovir?

Valacyclovir is being developed by Teva Pharmaceutical Industries Limited, a company traded on the New York Stock Exchange under the ticker TEVA. The company is conducting Phase 1 clinical trials to evaluate the drug's behavior in healthy subjects.

What phase is Valacyclovir in?

Valacyclovir is in Phase 1 clinical development. It has completed two Phase 1 trials, both involving healthy volunteers, with a total enrollment of 96 participants. The drug is investigational and has not received regulatory approval.

What clinical trials is Valacyclovir in?

Valacyclovir has two completed Phase 1 trials: NCT01149460, a study of a 1000 mg tablet under fed conditions in Canada with 36 participants, and NCT01149499, a study of the same tablet under fasting conditions in the United States with 60 participants. Both trials enrolled healthy adults aged 18 years and older.

Is Valacyclovir FDA approved?

Valacyclovir is not FDA approved. It is an investigational drug currently in Phase 1 clinical development, with all completed trials conducted in healthy volunteers. No approval status has been established, and the drug remains under clinical investigation.