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Topamax 2 x

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Sep 23, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment24
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00905567Topiramate 25 mg Tablets Under Fed ConditionsPHASE1 COMPLETED 24Jun 1, 2001Jun 1, 2001Sep 23, 20091 Canada
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Study Endpoints
Primary Endpoints
Cmax - Maximum Observed Concentration
Blood samples collected over 96 hour period

Bioequivalence based on Cmax

AUC0-72 - Area Under the Concentration Time Curve From Time Zero to Time 72 Hours (Per Participant)
Blood samples collected over 96 hour period

Bioequivalence based on AUC0-72

AUC0-t - Area Under the Concentration-time Curve From Time Zero to Time of Last Non-zero Concentration (Per Participant)
Blood samples collected over 96 hour period

Bioequivalence based on AUC0-t

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
Test FirstEXPERIMENTALTopiramate 2 x 25 mg Tablet
Reference FirstACTIVE_COMPARATORTopamax® Tablet 2 x 25 mg
Interventions
NameTypeDescription
Topiramate 2 x 25 mg tabletDRUG -
Topamax® Tablet 2 x 25 mgDRUG -
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Subjects will be females and/or males, non-smokers, 18 years of age or older * Subjects should read, sign and date an Informed Consent Form prior to any study procedures. * Female subjects will be post-menopausal or surgically sterilized. * Post menopausal status is defined as...

Countries:Canada
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