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Tamsulosin

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Aug 20, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment64
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01149746Tamsulosin Hydrochloride 0.4 mg Capsules Under Fasting ConditionsPHASE1 COMPLETED 32Dec 1, 2004Dec 1, 2004Jun 23, 20101 Canada
NCT01149733Tamsulosin Hydrochloride 0.4 mg Capsules Under Fed ConditionsPHASE1 COMPLETED 32Nov 1, 2004Nov 1, 2004Aug 20, 20241 Canada
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Study Endpoints
Primary Endpoints
Cmax (maximum observed concentration of drug substance in plasma)
Blood samples drawn over 60 hour time period

Bioequivalence based on Cmax

AUC0-t (area under the concentration-time curve from time zero to time of last measurable concentration)
Blood samples drawn over 60 hour time period

Bioequivalence based on AUC0-t

AUC0-inf (area under the concentration-time curve from time zero to infinity)
Blood samples drawn over 60 hour time period

Bioequivalence based on AUC0-inf

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
TamsulosinEXPERIMENTAL0.4 mg Capsule
Flomax®ACTIVE_COMPARATOR0.4 mg Capsule
Interventions
NameTypeDescription
TamsulosinDRUGTest 0.4 mg Capsule
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Eligibility Criteria
Age Range18 Years — N/A
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy, non-smoking male subjects, 18 years of age or older. * BMI greater than or equal to 19 and less than or equal to 30. * Negative for: * HIV. * Hepatitis B surface antigen and Hepatitis C antibody. * Using drugs of abuse test (marijuana, amphetamines, barbiturate...

Countries:Canada
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