Recent Updates
Recently added Catalysts

StemEx

Phase 2

Hematologic Malignancies | Small molecule | Oncology |Teva Pharmaceutical Industries Limited|Last Updated: Jul 10, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
UNCONTROLLEDDMC
Total Trials1
Total Enrollment101
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00469729Efficacy and Safety Study of StemEx®, to Treat Subjects With High Risk Hematologic Malignancies, Following Myeloablative TherapyPHASE2 COMPLETED 101Oct 1, 2007Jun 1, 2015Jul 10, 201530 United States, Hungary +3
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Overall 100-day mortality
100 days
Secondary Endpoints
180 day mortality, acute Graft versus Host Disease (GvHD) grades III-IV, engraftment failure
180 days
Safety and tolerability measures: The incidence and frequency of adverse experiences, acute toxicity, laboratory data and vital signs follow-up.
180 days
Proportion of overall mortality at 1 year
One year post transplant
Unlock Study Endpoints
Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
StemExEXPERIMENTAL -
Interventions
NameTypeDescription
StemEx®DRUGThe stem/progenitor cell based product composed of ex vivo expanded allogeneic umbilical cord blood cells, which is infused to subject at a rate of 1-3 ml/min in combination with non-manipulated cells derived from the same cord blood unit.
Unlock Study Design Details
Eligibility Criteria
Age Range12 Years — 55 Years
SexALL
Healthy VolunteersNo
Study Sites30

Inclusion Criteria: 1. Clinical diagnosis of AML or ALL: CR2 or subsequent complete remission (CR) or CR1 with high-risk features or relapse with \< 10% blasts in BM and no circulating blasts. 2. Clinical diagnosis of CML: in CP1 (Chronic Phase 1) and resistant or intolerant to Gleevec or in CP2 or...

Countries:United StatesHungaryIsraelItalySpain
Unlock Eligibility Criteria