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Ribavirin

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Aug 20, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment55
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00835146Ribavirin 200 mg Tablets Under Fasting ConditionsPHASE1 COMPLETED 28Sep 1, 2003Oct 1, 2003Aug 20, 20242 United States
NCT00835536Ribavirin 200 mg Tablets Under Non-Fasting ConditionsPHASE1 COMPLETED 27Sep 1, 2003Oct 1, 2003Aug 20, 20242 United States
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Study Endpoints
Primary Endpoints
Cmax (Maximum Observed Concentration of Drug Substance in Plasma)
Blood samples collected over a 72 hour period.

Bioequivalence based on Cmax.

AUC0-72 (Area Under the Concentration-time Curve From Time Zero to Time of 72 Hours)
Blood samples collected over a 72 hour period.

Bioequivalence based on AUC0-72.

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeOTHER
Treatment Arms
ArmTypeDescription
1EXPERIMENTAL -
2ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
Ribavirin 200 mg tabletsDRUG1 x 200 mg, single-dose fasting
COPEGUS™DRUG1 x 200 mg, single-dose fasting
COPEGUS™ 200 mg TabletsDRUG1 x 200 mg, single-dose non-fasting
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Eligibility Criteria
Age Range18 Years — N/A
SexFEMALE
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * All subjects selected for this study will be non-smokers, at least 18 years of age, and a female whi is physically unable to become pregnant (postmenopausal for at least 6 months or surgically sterile). Subjects will have a BMI (body mass index) of 30 or less. * Each subject s...

Countries:United States
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