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Prevacid

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Dec 8, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials3
Total Enrollment156
FDA Designations
No designations recorded
Clinical Trials (3)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01045967Lansoprazole 30 mg DR Capsule Fasting StudyPHASE1 COMPLETED 56May 1, 2004Jul 1, 2004Dec 8, 20101 United States
NCT01046253Lansoprazole 30 mg DR Capsule Fasting Replicate Sprinkle StudyPHASE1 COMPLETED 50Jan 1, 2004Jan 1, 2004Dec 8, 20101 United States
NCT01046084Lansoprazole 30 mg DR Capsule Replicate Food StudyPHASE1 COMPLETED 50Aug 1, 2003Sep 1, 2003Dec 8, 20101 United States
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Study Endpoints
Primary Endpoints
Cmax (Maximum Observed Concentration of Drug Substance in Plasma)
Blood samples collected over a 12 hour period.

Bioequivalence based on Cmax.

AUC0-t (Area Under the Concentration-time Curve From Time Zero to Time of Last Measurable Concentration)
Blood samples collected over a 12 hour period.

Bioequivalence based on AUC0-t.

AUC0-inf (Area Under the Concentration-time Curve From Time Zero to Infinity)
Blood samples collected over a 12 hour period.

Bioequivalence based on AUC0-inf.

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
Invesigational Test ProductEXPERIMENTALLansoprazole 30 mg delayed-release Capsules
Reference Listed DrugACTIVE_COMPARATORPrevacid® 30 mg delayed-release Capsules
Investigational Test ProductEXPERIMENTALLansoprazole 30 mg Delayed-Release Capsule
Interventions
NameTypeDescription
LansoprazoleDRUG30 mg delayed-release Capsule
Prevacid®DRUG30 mg delayed-release Capsule
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Non-smokers or light smokers (10 or less cigarettes per day) * 18 years of age or older * Body Mass Index of 30 or less * Males or non-pregnant females * Normal clinical laboratory test results Exclusion Criteria: * Subjects with a significant history of chronic alcohol cons...

Countries:United States
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