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Pramipexole

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Apr 30, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment48
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01074450Pramipexole Dihydrochloride 0.25 mg Tablets Under Fasting ConditionsPHASE1 COMPLETED 24Feb 1, 2005Mar 1, 2005Apr 30, 20101 United States
NCT01074463Pramipexole Dihydrochloride 0.25 mg Tablets Under Non-Fasting ConditionsPHASE1 COMPLETED 24Feb 1, 2005Mar 1, 2005Apr 30, 20101 United States
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Study Endpoints
Primary Endpoints
Cmax (Maximum Observed Concentration of Drug Substance in Plasma)
Blood samples collected over a 48 hour period.

Bioequivalence based on Cmax.

AUC0-t (Area Under the Concentration-time Curve From Time Zero to Time of Last Measurable Concentration)
Blood samples collected over a 48 hour period.

Bioequivalence based on AUC0-t.

AUC0-inf (Area Under the Concentration-time Curve From Time Zero to Infinity)
Blood samples collected over a 48 hour period.

Bioequivalence based on AUC0-inf.

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
1EXPERIMENTALPramipexole Dihydrochloride 0.25 mg Tablets
2ACTIVE_COMPARATORMirapex® 0.25 mg Tablets
Interventions
NameTypeDescription
Pramipexole DihydrochlorideDRUG0.25 mg Tablet
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Eligibility Criteria
Age Range18 Years — 45 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * All volunteers selected for this study will be healthy men and women 18 to 45 years of age, inclusive. * The weight range will not exceed + 20% for height and body frame as per Desirable Weight for Adults - 1983 Metropolitan Height and Weight Table. * Each volunteer will compl...

Countries:United States
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