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Pramipexole

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Apr 30, 2010

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLED
Total Trials2
Total Enrollment48

FDA Designations

No designations recorded

Clinical trial landscape

Pramipexole · 2 trials · 1 indication

Phase 1 2
NCT01074450Pramipexole Dihydrochloride 0.25 mg Tablets Under Fasting ConditionsHealthy
COMPLETED24 Analytics
NCT01074463Pramipexole Dihydrochloride 0.25 mg Tablets Under Non-Fasting ConditionsHealthy
COMPLETED24 Analytics
PHASE1COMPLETED
Pramipexole Dihydrochloride 0.25 mg Tablets Under Fasting Conditions
HealthyUnlock trial analytics
PHASE1COMPLETED
Pramipexole Dihydrochloride 0.25 mg Tablets Under Non-Fasting Conditions
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Cmax (Maximum Observed Concentration of Drug Substance in Plasma)
Blood samples collected over a 48 hour period.

Bioequivalence based on Cmax.

AUC0-t (Area Under the Concentration-time Curve From Time Zero to Time of Last Measurable Concentration)
Blood samples collected over a 48 hour period.

Bioequivalence based on AUC0-t.

AUC0-inf (Area Under the Concentration-time Curve From Time Zero to Infinity)
Blood samples collected over a 48 hour period.

Bioequivalence based on AUC0-inf.

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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER

Treatment Arms

ArmTypeDescription
1EXPERIMENTALPramipexole Dihydrochloride 0.25 mg Tablets
2ACTIVE_COMPARATORMirapex® 0.25 mg Tablets

Interventions

NameTypeDescription
Pramipexole DihydrochlorideDRUG0.25 mg Tablet
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Eligibility Criteria

Age Range18 Years to 45 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * All volunteers selected for this study will be healthy men and women 18 to 45 years of age, inclusive. * The weight range will not exceed + 20% for height and body frame as per Desirable Weight for Adults - 1983 Metropolitan Height and Weight Table. * Each volunteer will compl...

Countries:United States
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Frequently asked questions about Pramipexole

What is Pramipexole used for?

Pramipexole is a small molecule drug being developed by Teva Pharmaceutical Industries Limited (TEVA). It is currently in Phase 1 clinical trials, studied in healthy volunteers to assess the effects of Pramipexole Dihydrochloride 0.25 mg tablets under fasting and non-fasting conditions.

Who makes Pramipexole?

Pramipexole is developed by Teva Pharmaceutical Industries Limited, a company listed on the stock exchange under the ticker symbol TEVA. The drug is currently in Phase 1 clinical development.

What phase is Pramipexole in?

Pramipexole is in Phase 1 clinical development. It is an investigational drug, not yet approved, and is being studied in healthy volunteers to evaluate the pharmacokinetics of Pramipexole Dihydrochloride 0.25 mg tablets.

What clinical trials is Pramipexole in?

Pramipexole has two completed Phase 1 clinical trials: NCT01074450, studying the drug under fasting conditions, and NCT01074463, studying it under non-fasting conditions. Both trials enrolled 24 healthy volunteers each in the United States, with a minimum age of 18 years.

Is Pramipexole the same as Pramipexole Dihydrochloride?

Pramipexole is the active ingredient in the drug product Pramipexole Dihydrochloride. The clinical trials for Pramipexole use the dihydrochloride salt form, administered as 0.25 mg tablets.