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PROZAC WEEKLY

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Feb 21, 2011

Success Probability

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Market & Valuation

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Trial Design

RandomizedACTIVE_CONTROLLED
Total Trials2
Total Enrollment52

FDA Designations

No designations recorded

Clinical trial landscape

PROZAC WEEKLY · 2 trials · 1 indication

Phase 1 2
NCT0124727290 mg Fluoxetine Hydrochloride Capsules Under Fasting ConditionsHealthy
COMPLETED26 Analytics
NCT0124728590 mg Fluoxetine Hydrochloride Capsules Under Non-Fasting ConditionsHealthy
COMPLETED26 Analytics
PHASE1COMPLETED
90 mg Fluoxetine Hydrochloride Capsules Under Fasting Conditions
HealthyUnlock trial analytics
PHASE1COMPLETED
90 mg Fluoxetine Hydrochloride Capsules Under Non-Fasting Conditions
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Cmax of Fluoxetine.
Blood samples collected over a 25 day period.

Bioequivalence based on Fluoxetine Cmax (maximum observed concentration of drug substance in plasma).

AUC0-t of Fluoxetine.
Blood samples collected over a 25 day period.

Bioequivalence based on Fluoxetine AUC0-t (area under the concentration-time curve from time zero to time of last measurable concentration).

AUC0-inf of Fluoxetine.
Blood samples collected over a 25 day period.

Bioequivalence based on Fluoxetine AUC0-inf (area under the concentration-time curve from time zero to infinity).

Secondary Endpoints

Cmax of Norfluoxetine.
Blood samples collected over a 25 day period.
AUC0-t of Norfluoxetine.
Blood samples collected over a 25 day period.
AUC0-inf of Norfluoxetine.
Blood samples collected over a 25 day period.
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER

Treatment Arms

ArmTypeDescription
Reference Listed DrugACTIVE_COMPARATOR90 mg PROZAC WEEKLY® Capsules (Eli Lilly)
Investigational Test ProductEXPERIMENTAL90 mg Fluoxetine Hydrochloride Capsules (Teva)

Interventions

NameTypeDescription
Fluoxetine HydrochlorideDRUG90 mg Capsules
PROZAC WEEKLY®DRUG90 mg Capsules
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Screening Demographics: All volunteers selected for this study will be healthy men and women 18 years of age or older at the time of dosing. The weight range will not exceed + 15% for height and body frame as per Desirable Weights for Men - 1983 Metropolitan Height and Weight ...

Countries:United States
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Frequently asked questions about PROZAC WEEKLY

What is PROZAC WEEKLY?

PROZAC WEEKLY is a small molecule drug being developed by Teva Pharmaceutical Industries Limited (TEVA). It is currently in Phase 1 clinical development. The drug is being studied in healthy volunteers, and it is not yet approved for any indication.

What is PROZAC WEEKLY used for?

PROZAC WEEKLY is being studied for use in healthy volunteers. It is currently in Phase 1 clinical trials, which are designed to evaluate the drug's safety and pharmacokinetics in healthy individuals. The drug is not yet approved for any specific medical condition.

Who makes PROZAC WEEKLY?

PROZAC WEEKLY is being developed by Teva Pharmaceutical Industries Limited, a company traded on the stock exchange under the ticker symbol TEVA. The drug is currently in Phase 1 clinical development.

What phase is PROZAC WEEKLY in?

PROZAC WEEKLY is in Phase 1 clinical development. It has completed two Phase 1 trials, both of which were conducted in healthy volunteers. The drug is investigational and has not been approved by regulatory authorities.

What clinical trials is PROZAC WEEKLY in?

PROZAC WEEKLY has completed two Phase 1 clinical trials: NCT01247272, a study of 90 mg fluoxetine hydrochloride capsules under fasting conditions, and NCT01247285, a study of the same capsules under non-fasting conditions. Both trials enrolled 26 healthy volunteers each in the United States.

Is PROZAC WEEKLY the same as fluoxetine?

PROZAC WEEKLY is a formulation of fluoxetine hydrochloride, as indicated by the clinical trial titles for the 90 mg capsules. It is being developed by Teva Pharmaceutical Industries Limited and is currently in Phase 1 clinical trials.