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Finasteride

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Aug 19, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment52
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00835666Finasteride 5 mg Tablets Under Fasting ConditionsPHASE1 COMPLETED 32Jun 1, 2002Jun 1, 2002Aug 19, 20241 United States
NCT00835796Finasteride 5 mg Tablets, Non-fastingPHASE1 COMPLETED 20Jun 1, 2002Jul 1, 2002Aug 19, 20241 United States
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Study Endpoints
Primary Endpoints
Cmax - Maximum Observed Concentration
Blood samples collected over 36 hour period

Bioequivalence based on Cmax

AUCinf - Area Under the Concentration-time Curve From Time Zero to Infinity (Extrapolated)
Blood samples collected over 36 hour period

Bioequivalence based on AUCinf

AUC0-t - Area Under the Concentration-time Curve From Time Zero to Time of Last Non-zero Concentration (Per Participant)
Blood samples collected over 36 hour period

Bioequivalence based on AUC0-t

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeOTHER
Treatment Arms
ArmTypeDescription
FinasterideEXPERIMENTALFinasteride 5 mg Tablet (test) dosed in first period followed by Proscar® 5 mg Tablet (reference) dosed in second period
Proscar®ACTIVE_COMPARATORProscar® 5 mg Tablet (reference) dosed in first period followed by Finasteride 5 mg Tablet (test) dosed in second period
Interventions
NameTypeDescription
Finasteride 5 mg tabletsDRUG1 x 5 mg, single dose fasting
PROSCAR®DRUG1 x 5 mg, single dose fasting
PROSCAR® 5mg tabletsDRUG1 x 5 mg, single dose fasting
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Eligibility Criteria
Age Range18 Years — N/A
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * All subjects selected for this study will be male non-smokers at least 18 years of age. Subjects will have a BMI (body mass index) of 30 or less. * Each subject shall be given a general physical examination within 28 days of initiation of the study. Such examination includes, ...

Countries:United States
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