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Dexmethylphenidate

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Aug 19, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment48
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00829673Dexmethylphenidate Hydrochloride Tablets Under Non-Fasting ConditionsPHASE1 COMPLETED 24Jun 1, 2004Jun 1, 2004Aug 19, 20241 United States
NCT00829712Dexmethylphenidate Hydrochloride Tablets Under Fasting ConditionsPHASE1 COMPLETED 24Jun 1, 2004Jun 1, 2004Aug 19, 20241 United States
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Study Endpoints
Primary Endpoints
Cmax (Maximum Observed Concentration)
Blood samples collected over a 16 hour period.

Bioequivalence based on Cmax.

AUC0-t (Area Under the Concentration-time Curve From Time Zero to Time of Last Measurable Concentration)
Blood samples collected over a 16 hour period.

Bioequivalence based on AUC0-t.

AUC0-inf (Area Under the Concentration-time Curve From Time Zero to Infinity)
Blood samples collected over a 16 hour period.

Bioequivalence based on AUC0-inf.

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeOTHER
Treatment Arms
ArmTypeDescription
1EXPERIMENTAL -
2ACTIVE_COMPARATORFocalin®
Interventions
NameTypeDescription
Dexmethylphenidate HydrochlorideDRUG10 mg Tablet
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria 1. Sex: Male and Female; similar proportion of each preferred. 2. Age: At least 18 years. 3. Weight: BMI (Body Mass Index) less than or equal to 30. 4. Qualifying subjects must be in good health and physical condition as determined by medical history, complete physical examinatio...

Countries:United States
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