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ALLEGRA

Phase 1

Healthy | Small molecule | Other |Teva Pharmaceutical Industries Limited|Last Updated: Aug 20, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials2
Total Enrollment84
FDA Designations
No designations recorded
Clinical Trials (2)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00835276Fexofenadine Hydrochloride 180 mg Tablets Under Fasting ConditionsPHASE1 COMPLETED 60Mar 1, 2002Mar 1, 2002Aug 20, 20091 United States
NCT00835640Fexofenadine Hydrochloride 180 mg Tablets Under Non-Fasting ConditionsPHASE1 COMPLETED 24Jan 1, 2002Jan 1, 2002Aug 20, 20091 United States
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Study Endpoints
Primary Endpoints
Cmax = Maximum Observed Concentration.
Blood samples collected over a 48 hour period.

Bioequivalence based on Cmax.

AUC0-t = Area Under the Concentration-time Curve From Time Zero to Time of Last Measurable Concentration (Per Participant)
Blood samples collected over a 48 hour period.

Bioequivalence based on AUC0-t.

AUC0-inf = Area Under the Concentration-time Curve From Time Zero to Infinity.
Blood samples collected over a 48 hour period.

Bioequivalence based on AUC0-inf.

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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
1EXPERIMENTAL -
2ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
Fexofenadine 180 mg tabletsDRUG1 x 180 mg
ALLEGRA® 180 mg tabletsDRUG1 x 180 mg
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Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * All volunteers selected for this study will be healthy, non-smoking men and women 18 to 55 years of age, inclusive, at the time of dosing. The volunteer's body mass index (BMI) is less that or equal to 30. * If female and : * of child bearing potential, is practicing an acc...

Countries:United States
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