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Indocyanine Green

Phase 1

Lower Extremity Lymphedema | Small molecule | Other |Tactile Systems Technology, Inc.|Last Updated: Aug 11, 2026

Target and mechanism

ModalitySmall molecule

Also known as Indocyanine Green (IC-Green)

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment5

FDA Designations

No designations recorded

Clinical trial landscape

Indocyanine Green · 1 trial · 1 indication

Early Phase 1 1
NCT07613931Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema TreatmentLower Extremity Lymphedema
RECRUITING5 Analytics
EARLY_PHASE1RECRUITING
Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment
Lower Extremity LymphedemaUnlock trial analytics

Study Endpoints

Primary Endpoints

Lymphatic anatomy
Before and after 60-minute treatment in clinic with APCD

• The distance (cm) that lymph travels from injection sites

Lymphatic propulsion
Before and after 60-minute treatment in clinic with APCD

• Number of lymph propulsion events per minute

Secondary Endpoints

Evaluate swelling in treatment limbs
Before and after 60-minute treatment in clinic with APCD
Adverse Events
Through completion of study at Visit 2, up to 4 weeks
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeDEVICE_FEASIBILITY

Treatment Arms

ArmTypeDescription
Treatment groupEXPERIMENTAL -

Interventions

NameTypeDescription
Advanced pneumatic compression device (APCD)DEVICESingle APCD treatment session at visit 1
Advanced pneumatic compression device (APCD) with revised compression programmingDEVICEAPCD with revised compression programming will be single treatment session at visit 2
Indocyanine Green (IC-Green)DRUGIndocyanine Green dye will be used to assess primary endpoint
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. 18 years of age or older 2. A diagnosis of active lower extremity lymphedema, as assessed by medical history 3. Participant is a candidate for APCD treatment per the Flexitouch Plus indications for use 4. Must be able to provide informed consent prior to study participation 5...

Countries:United States
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Recent Changes (Last 90 Days)

LOWAug 16, 2026NCT07613931startDate: changed
LOWAug 16, 2026NCT07613931startDate: changed
LOWAug 16, 2026NCT07613931startDate: changed
LOWJul 8, 2026NCT07613931Status: NOT_YET_RECRUITING → RECRUITING
LOWJul 8, 2026NCT07613931Status: NOT_YET_RECRUITING → RECRUITING

Frequently asked questions about Indocyanine Green

What is Indocyanine Green used for?

Indocyanine Green is being studied for use in lower extremity lymphedema. It is an investigational small molecule being developed by Tactile Systems Technology, Inc. The drug is currently in early Phase 1 clinical development for this condition.

What does Indocyanine Green target?

Indocyanine Green is a small molecule being evaluated for lower extremity lymphedema. Its specific molecular target has not been disclosed in available clinical trial information. The drug is in early Phase 1 development.

Who makes Indocyanine Green?

Indocyanine Green is being developed by Tactile Systems Technology, Inc., a company traded on the NASDAQ under the ticker TCMD. The drug is currently in early Phase 1 clinical trials for lower extremity lymphedema.

What phase is Indocyanine Green in?

Indocyanine Green is in early Phase 1 clinical development. It is an investigational drug being studied for lower extremity lymphedema, and it is not yet approved for any use. The ongoing trial is recruiting participants in the United States.

What clinical trials is Indocyanine Green in?

Indocyanine Green is being studied in one active clinical trial, NCT07613931, titled "Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment." This early Phase 1 trial is recruiting 5 participants with lower extremity lymphedema in the United States.

Is Indocyanine Green the same as IC-Green?

Yes, Indocyanine Green is also known as IC-Green. The drug is being developed by Tactile Systems Technology, Inc. for lower extremity lymphedema and is currently in early Phase 1 clinical trials.