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TD-1211 Dose 1

Phase 1

Constipation | Small molecule | Gastrointestinal |Theravance Biopharma, Inc.|Last Updated: Jan 14, 2021

Success Probability

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Market & Valuation

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Trial Design

CONTROLLED
Total Trials1
Total Enrollment47

FDA Designations

No designations recorded

Clinical trial landscape

TD-1211 Dose 1 · 1 trial · 1 indication

Phase 1 1
NCT01655771TD-1211 Single-Dose Study in Elderly and Young Healthy SubjectsConstipation
COMPLETED47 Analytics
PHASE1COMPLETED
TD-1211 Single-Dose Study in Elderly and Young Healthy Subjects
ConstipationUnlock trial analytics

Study Endpoints

Primary Endpoints

Cmax
0-96 hours
AUCt
Based on samples collected 0-96 hours
AUCinf
Based on samples collected 0-96 hours

Secondary Endpoints

Number of patients with treatment-emergent adverse events
Days 1-14
Number patients with abnormal vital sign measurements
Days 1-5
Number of patients with abnormal clinical laboratory results
Days 1-5
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ElderlyEXPERIMENTALTD-1211 Dose 1
YoungerEXPERIMENTALTD-1211 Dose 2

Interventions

NameTypeDescription
TD-1211 Dose 1DRUG -
TD-1211 Dose 2DRUG -
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Eligibility Criteria

Age Range18 Years to 85 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * For the elderly cohort, nonsmoking 65 to 85 years, inclusive. For the young cohort, nonsmoking 18 to 45 years, inclusive. * Body mass index (BMI) should be 18 to 36 kg/m2, inclusive. * At screening, sitting or supine heart rate of 50 to 100 beats per minute and sitting or supi...

Countries:United States
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Frequently asked questions about TD-1211 Dose 1

What is TD-1211 Dose 1 used for?

TD-1211 Dose 1 is an investigational small molecule being developed for the treatment of constipation. It is currently in Phase 1 clinical development and has not been approved by regulatory authorities. The drug is being studied for its potential to address constipation, a gastrointestinal condition.

Who makes TD-1211 Dose 1?

TD-1211 Dose 1 is being developed by Theravance Biopharma, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol TBPH. The company is conducting clinical trials to evaluate the safety and tolerability of this investigational drug for constipation.

What phase is TD-1211 Dose 1 in?

TD-1211 Dose 1 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA or any other regulatory agency. The drug is being studied in early-stage clinical trials to assess its safety, tolerability, and pharmacokinetics in healthy subjects.

What clinical trials is TD-1211 Dose 1 in?

TD-1211 Dose 1 has been studied in one completed Phase 1 clinical trial, identified as NCT01655771. This trial, titled 'TD-1211 Single-Dose Study in Elderly and Young Healthy Subjects,' enrolled 47 participants in the United States. The study was controlled but not randomized or double-blinded, and it included healthy volunteers aged 18 years and older.

Is TD-1211 Dose 1 FDA approved?

No, TD-1211 Dose 1 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development for the treatment of constipation. The drug has not completed the clinical trials and regulatory review process required for marketing approval.