Recent Updates
Recently added Catalysts

lotilaner

Phase 2

Ocular Rosacea | Small molecule | Dermatology |Tarsus Pharmaceuticals, Inc.|Last Updated: Mar 2, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindCONTROLLEDBiomarker
Total Trials1
Total Enrollment155
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07443202Study of Lotilaner Ophthalmic Gel in Patients With Ocular Rosacea (KORE)PHASE2 ENROLLING BY_INVITATION 155Dec 5, 2025Dec 31, 2027Mar 2, 20262 United States
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Incidence of Treatment Emergent Adverse Events
Week 16

Number of patients with treatment related emergent adverse events (TEAEs)

Secondary Endpoints
Intraocular pressure
Week 16
Visual acuity
Week 16
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Treatment armEXPERIMENTALlotilaner - high dose and low dose
Control armOTHERVehicle of lotilaner - high dose and low dose
Interventions
NameTypeDescription
lotilanerDRUGlotilaner
VehicleDRUGVehicle of lotilaner
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: * 18 years of age or older at the time of consent. * Has moderate to severe ocular rosacea * Use of acceptable methods of contraception * Are willing to sign the informed consent form and is deemed capable of complying with the requirements of the study protocol Exclusion Crite...

Countries:United States
Unlock Eligibility Criteria
Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT07443202primaryCompletionDate: changed
LOWMay 24, 2026NCT07443202studyFirstPostDate: changed