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Vyvanse

Phase 3

ADHD | Small molecule | Psychiatry |Takeda Pharmaceutical Company Limited|Last Updated: Jun 14, 2021

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment129

FDA Designations

No designations recorded

Clinical trial landscape

Vyvanse · 1 trial · 1 indication

Phase 3 1
NCT00500149A Classroom Study to Assess the Time of Onset of Vyvanse (Lisdexamfetamine Dimesylate) in Pediatric Subjects Aged 6-12 With Attention Deficit/Hyperactivity Disorder (ADHD)ADHD
COMPLETED129 Analytics
PHASE3COMPLETED
A Classroom Study to Assess the Time of Onset of Vyvanse (Lisdexamfetamine Dimesylate) in Pediatric Subjects Aged 6-12 With Attention Deficit/Hyperactivity Disorder (ADHD)
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Study Endpoints

Primary Endpoints

Onset of Effect of Vyvanse
Evaluations were conducted at 1.5, 2.5, 5.0, 7.5, 10.0, 12.0, and 13.0 hours post-dose.

The onset of effect will be defined as the first assessment time showing statistical significance between Vyvanse and placebo as measured by the Swanson, Kotkin, Agler, M-Flynn, and Pelham (SKAMP) Deportment scale. The degree of impairment is rated from 0 (normal) to 6 (maximal).

Secondary Endpoints

Duration of Effect of Vyvanse
Evaluations were conducted at 1.5, 2.5, 5.0, 7.5, 10.0, 12.0, and 13.0 hours post-dose.
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelCROSSOVER
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
1EXPERIMENTAL -
2PLACEBO_COMPARATOR -

Interventions

NameTypeDescription
Vyvanse (lisdexamfetamine dimesylate)DRUGFollowing completion of the open-label dose optimization period and successful titration to an optimal dose of Vyvanse™, subjects will take their optimized dose of Vyvanse™ (30, 50 or 70 mg/day).
PlaceboDRUGPlacebo
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Eligibility Criteria

Age Range6 Years to 12 Years
SexALL
Healthy VolunteersNo
Study Sites9

Inclusion Criteria: 1. Subject is a male or female aged 6-12 years inclusive at the time of consent. 2. Females of Child-bearing Potential (FOCP) must have a negative serum beta Human Chorionic Gonadotropin (HCG) pregnancy test at Screening and a negative urine pregnancy test at Baseline and agree ...

Countries:United States
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Competitive Landscape -ADHD 3 trials

CompanyTickerTrialsLead PhaseDrugs
Supernus Pharmaceuticals, Inc.SUPN1PHASE3SPN-812
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Frequently asked questions about Vyvanse

What is Vyvanse used for?

Vyvanse is used for the treatment of attention deficit/hyperactivity disorder (ADHD). It is a small molecule psychiatric medication being developed by Takeda Pharmaceutical Company Limited. The drug has been studied in a Phase 3 clinical trial for this indication.

Who makes Vyvanse?

Vyvanse is developed by Takeda Pharmaceutical Company Limited, which trades under the ticker symbol TAK. The drug is a small molecule being studied for the treatment of ADHD in the therapeutic area of psychiatry.

What phase is Vyvanse in?

Vyvanse is in Phase 3 clinical development. It has completed one Phase 3 trial for ADHD. The drug is investigational and has not been approved by regulatory authorities based on the available information.

What clinical trials is Vyvanse in?

Vyvanse has been studied in one completed Phase 3 clinical trial with the identifier NCT00500149. This was a randomized, double-blind, placebo-controlled classroom study that assessed the time of onset of Vyvanse in pediatric subjects aged 6-12 with ADHD.

Is Vyvanse the same as lisdexamfetamine dimesylate?

Yes, Vyvanse is the brand name for lisdexamfetamine dimesylate. The clinical trial NCT00500149 specifically evaluated Vyvanse (lisdexamfetamine dimesylate) in pediatric subjects with ADHD, confirming that these names refer to the same drug.