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TachoSil

Phase 3

Hemorrhage | Monoclonal antibody | Other |Takeda Pharmaceutical Company Limited|Last Updated: Nov 25, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment253
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01192022TachoSil® Versus Surgicel® Original for the Secondary Treatment of Local Bleeding in Adult and Pediatric Patients Undergoing Hepatic Resection SurgeryPHASE3 COMPLETED 253Aug 1, 2010May 1, 2013Nov 25, 201517 United States
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Study Endpoints
Primary Endpoints
Percentage of Participants With Intraoperative Hemostasis at Target Bleeding Site Within 3 Minutes
within 3 minutes

3 Minutes after the patch was applied to the target bleeding area, the area was observed to see if the bleeding stopped.

Secondary Endpoints
Percentage of Participants With Intraoperative Hemostasis at Target Bleeding Site Within 5 Minutes
within 5 minutes
Time to Intraoperative Hemostasis at Target Bleeding Site
10 minutes
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
TachoSil®ACTIVE_COMPARATORTachoSil® absorbable patches, applied topically, once, intraoperatively to stop bleeding. The number of patches used was determined by the surgeon based on the size of the wound. If bleeding did not stop after 5 minutes treatment was repeated.
Surgicel® OriginalACTIVE_COMPARATORSurgicel® Original absorbable patches, applied topically, once, intraoperatively to stop bleeding. The number of patches used was determined by the surgeon based on the size of the wound. If bleeding did not stop after 5 minutes treatment was repeated.
Interventions
NameTypeDescription
TachoSil®BIOLOGICALIntraoperative application as secondary hemostatic treatment
Surgicel® OriginalDEVICEIntraoperative application as secondary hemostatic treatment
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Eligibility Criteria
SexALL
Healthy VolunteersNo
Study Sites17

Inclusion Criteria: * Resection of at least the equivalent tissue volume of 1 anatomical segment of the liver * Minor to moderate (oozing/diffuse) bleeding from the resection area persisting after conventional resection procedure and primary control of arterial pulsating bleeding or major venous he...

Countries:United States
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