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TAK-816+ DPT-TAKEDA

Phase 3

Immunization | Monoclonal antibody | Other |Takeda Pharmaceutical Company Limited|Last Updated: Mar 5, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLED
Total Trials1
Total Enrollment416
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01379846Study of TAK-816 in Healthy InfantsPHASE3 COMPLETED 416Jun 1, 2011Feb 1, 2013Mar 5, 201322 Japan
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Study Endpoints
Primary Endpoints
Proportion of participants with an anti-polyribosylribitol phosphate (PRP) titer ≥1 ϻg/mL
4 weeks after the third dose (Visit 4)
Secondary Endpoints
Proportion of participants with an anti-polyribosylribitol phosphate (PRP) titer ≥0.15 ϻg/mL
4 weeks after the third dose (Visit 4)
Proportion of participants with an anti-PRP geometric mean titers (GMT)
4 weeks after the third dose (Visit 4)
Proportion of participants with an anti-PRP titer ≥1 ϻg/mL
4 weeks after the single booster dose. (Visit 6)
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
TAK-816EXPERIMENTAL -
ActHIBACTIVE_COMPARATOR -
Interventions
NameTypeDescription
TAK-816+ DPT-TAKEDABIOLOGICALTAK-816 0.5 mL and DPT-TAKEDA 0.5.mL, subcutaneous injections, three doses administered at 4-week intervals over 8 weeks, followed by a fourth dose 52 weeks after third dose.
ActHIB+ DPT-TAKEDABIOLOGICALActHIB 0.5 mL and DPT-TAKEDA 0.5.mL, subcutaneous injections, three doses administered at 4-week intervals over 8 weeks, followed by a fourth dose 52 weeks after third dose.
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Eligibility Criteria
Age Range3 Months — 6 Months
SexALL
Healthy VolunteersYes
Study Sites22

Inclusion Criteria: 1. Male or female infants aged ≥3 and \<7 months (excluding hospitalized infants). 2. Infants whose legal acceptable representatives have given informed consent to the study prior to enrollment. 3. Infants whose parents or legal guardians have agreed to cooperate with the invest...

Countries:Japan
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