Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT00151918 | Efficacy and Safety of Lanthanum Carbonate and Sevelamer Hydrochloride in Patients Receiving Haemodialysis for End Stage Renal Disease | PHASE3 | COMPLETED | 48 | — | — | Jan 7, 2005 | Aug 22, 2005 | Jul 6, 2021 | - | — |
| NCT00151931 | Efficacy and Tolerability of Treatment With Lanthanum Carbonate in Patients With End Stage Renal Disease Receiving Dialysis | PHASE3 | COMPLETED | 456 | — | — | May 11, 2004 | Jan 12, 2006 | Jun 8, 2021 | - | — |
| NCT00150566 | Efficacy and Safety of Lanthanum in Controlling Serum Phosphate Levels in Subjects With End Stage Renal Disease Who Require Treatment for High Levels of Phosphate in Their Blood | PHASE3 | COMPLETED | 460 | — | — | Feb 9, 2004 | Oct 8, 2005 | Jun 8, 2021 | - | — |
| NCT00150540 | A Long Term Study of Lanthanum Carbonate in Patients Requiring Dialysis Who Have Ived Lanthanum Carbonate in Previous Studies Defined by the Protocol. | PHASE3 | COMPLETED | 93 | — | — | Oct 14, 2002 | Jun 29, 2005 | Jun 23, 2021 | - | — |
| NCT00875017 | Comparing Absorption of Dietary Phosphorus When Administering FOSRENOL® or RENVELA® in Healthy Adult Volunteers | PHASE1 | COMPLETED | 31 | — | — | Apr 20, 2009 | Jun 16, 2009 | Jun 15, 2021 | 1 | United States |
Net phosphorous absorption (Lanthanum carbonate period) = phosphorous ingested in meal minus (Rectal effluent phosphorous after Lanthanum carbonate + meal minus Rectal effluent phosphorous after fasting). Net phosphorous absorption (Sevelamer Carbonate period) = Phosphorous ingested in meal minus (Rectal effluent phosphorous after Sevelamer carbonate + meal minus Rectal effluent phosphorous after fasting). Net phosphorous absorption (Meal only period) = Phosphorous ingested in meal minus (Rectal effluent phosphorous after meal only minus Rectal effluent phosphorous after fasting).
| Arm | Type | Description |
|---|---|---|
| Meal + Lanthanum | EXPERIMENTAL | - |
| Meal + Sevelamer | ACTIVE_COMPARATOR | - |
| Meal Only | NO_INTERVENTION | - |
| Fasting | NO_INTERVENTION | - |
| Name | Type | Description |
|---|---|---|
| Lanthanum carbonate | DRUG | - |
| Sevelamer | DRUG | 3 x 800mg tablets |
Inclusion Criteria: * Patients receiving haemodialysis for ESRD * Patients must have received haemodialysis for chronic renal failure three times per week for at least the previous 2 months Exclusion Criteria: * Pregnant or lactating women * Patients with clinically significant uncontrolled concu...